29844-80-2

Basic information

• Product Name: 3-ACETYLNORADAMANTANE
• Synonyms: 3-ACETYLNORADAMANTANE;1-(octahydro-2,5-methanopentalen-3a-yl)ethanone
• CAS NO: 29844-80-2
• Molecular Formula: C11H16O
• Molecular Weight: 164.24
• Mol File: 29844-80-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 212 °C(lit.)
• Flash Point: 215 °F
• Appearance: /
• Density: 1.044 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.502(lit.)
• CAS DataBase Reference: 3-ACETYLNORADAMANTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETYLNORADAMANTANE(29844-80-2)
• EPA Substance Registry System: 3-ACETYLNORADAMANTANE(29844-80-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 29844-80-2(Hazardous Substances Data)

Usage

Uses

3-?Acetylnoradamantane is a stain/dye.Dyes and metabolites.

InChI:InChI=1S/C11H16O/c1-6(12)11-9-3-7-2-8(5-9)10(11)4-7/h7-11H,2-5H2,1H3

Upstream product

• 702-98-7 2-methyl-2-adamantanol 
• 16200-53-6 3-noradamantanecarboxylic acid 
• 917-54-4 methyllithium 
• 29844-79-9 3-chlorobicyclo<3.3.1>nonan-7-yl methyl ketone 
• 29844-79-9 3-chlorobicyclo<3.3.1>non-7-yl methyl ketone 
• 29844-79-9 7-chlorobicyclo<3.3.1>non-3-yl methyl ketone 
• 702-98-7 2-methyladamantan-2-ol 
• 64-19-7 acetic acid 
• 700-58-3 2-Adamantanone 
• 29844-86-8 2-methyladamantan-2-yl hypochlorite 

Downstream Products

• 17471-43-1 3-noradamantane-methanol 
• 16200-53-6 3-noradamantanecarboxylic acid 

Relevant articles and documents

Preparative Flash Vacuum Thermolysis. Formation of 3-Noradamantylacetylene via Adamantylidenecarbene

3-Ethynyltricyclo3,7>nonane is conveniently prepared from adamantanone, via an anomalous alkylidenecarbene rearrangement, by flash vacuum thermolysis of 5-adamantylidene-2,2-dimethyl-1,3-dioxane-4,6-dione.

Discovery of adamantane based highly potent HDAC inhibitors

Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors were designed, synthesized and screened for the inhibitory activity of HDAC. A number of compounds exhibited GI50 of 10-100 nM in human HCT116, NCI-H460 and U251 cancer cells, in vitro. Compound 32 displays efficacy in human tumour animal xenograft model.

HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS

Described are bridged compounds of the formula (I), their analogs, tautomeric forms, stereoisomers, geometrical isomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The invention relates to compositions and methods to treat fungal infection. These compounds are selective HDAC inhibitors that act as inherent antifungal compounds or enhance the activity of other antifungal compounds such as azoles.

SYNTHESIS OF 3-NORADAMANTAMINE

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