298690-89-8

Basic information

• Product Name: (R)-2-(4-Fluorophenyl)pyrrolidine
• Synonyms: (R)-2-(4-Fluorophenyl)pyrrolidine;(2R)-2-(4-fluorophenyl)pyrrolidine;(R)-2-(4-FLUOROPHENYL)PYRROLIDINE-HCL
• CAS NO: 298690-89-8
• Molecular Formula: C₁₀H₁₂FN
• Molecular Weight: 165.21
• Product Categories: API intermediates
• Mol File: 298690-89-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 235.5 °C at 760 mmHg
• Flash Point: 96.3 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.0497mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.76±0.10(Predicted)
• CAS DataBase Reference: (R)-2-(4-Fluorophenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-Fluorophenyl)pyrrolidine(298690-89-8)
• EPA Substance Registry System: (R)-2-(4-Fluorophenyl)pyrrolidine(298690-89-8)

Safety Data

• Hazardous Substances Data: 298690-89-8(Hazardous Substances Data)

Usage

General Description

(R)-2-(4-Fluorophenyl)pyrrolidine is a chemical compound with the molecular formula C10H12FNO. It is a chiral pyrrolidine derivative with a 4-fluorophenyl group attached to the second carbon of the pyrrolidine ring. (R)-2-(4-Fluorophenyl)pyrrolidine has been studied for its potential pharmacological properties, including as a potential drug target for various neurological and psychiatric conditions. It may also have potential applications in medicinal chemistry and drug discovery. The compound's chiral nature suggests that it may have different biological activities depending on the stereochemistry of its enantiomers. Further research is needed to fully understand the potential uses and implications of (R)-2-(4-Fluorophenyl)pyrrolidine in various fields.

InChI:InChI=1/C10H12FN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2/t10-/m1/s1

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 22217-86-3 2-(4-fluorophenyl)-Δ¹-pyrrolidine 
• 1765-93-1 4-fluoroboronic acid 
• 298690-60-5 (R)-2-(4-fluorophenyl)-1-tosylpyrrolidine 

Downstream Products

• 885044-22-4 (R)-tert-butyl 2-(4-fluorophenyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Tackling N-Alkyl Imines with 3d Metal Catalysis: Highly Enantioselective Iron-Catalyzed Synthesis of α-Chiral Amines

A readily activated iron alkyl precatalyst effectively catalyzes the highly enantioselective hydroboration of N-alkyl imines. Employing a chiral bis(oxazolinylmethylidene)isoindoline pincer ligand, the asymmetric reduction of various acyclic N-alkyl imines provided the corresponding α-chiral amines in excellent yields and with up to >99 % ee. The applicability of this base metal catalytic system was further demonstrated with the synthesis of the pharmaceuticals Fendiline and Tecalcet.

Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination

Chiral cyclic amines can be prepared via intramolecular reductive amination of N-Boc-protected amino ketones in a one-pot process. With the complex of iridium and f-spiroPhos as the catalyst, a range of N-Boc-protected amino ketones are smoothly transformed into chiral cyclic free amines in high yields and excellent enantioselectivities (up to 97% ee). Moreover, this method can also be successfully applied to the synthesis of a κ-opioid receptor selective antagonist, (S)-1.

Asymmetric reduction of cyclic imines catalyzed by a whole-cell biocatalyst containing an (S)-imine reductase

Biocatalytic imine reduction: A whole-cell recombinant E. coli system, producing an (S)-selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This biocatalyst is used for the enantioselective reduction of a broad range of substrates such as dihydroisoquinolines and dihydro-β- carbolines as well as iminium ions. Copyright