299-35-4 Usage
Description
THIOTHIAMINE, also known as Thiamine Impurity A, is an impurity found in Thiamine (T344185). It is a chemical compound that has been identified for its inhibitory effects on the activity of glutamate decarboxylase, an enzyme responsible for the conversion of glutamate to gamma-aminobutyric acid (GABA). By inhibiting this enzyme, THIOTHIAMINE leads to a decrease in the concentration of GABA in brain tissue.
Uses
Used in Pharmaceutical Industry:
THIOTHIAMINE is used as a research compound for understanding the role of GABA in the brain and its relationship with various neurological disorders. Its inhibitory effect on glutamate decarboxylase makes it a valuable tool in studying the regulation of GABA levels and the potential therapeutic applications in conditions such as epilepsy, anxiety, and other neurological disorders.
Used in Neurochemical Research:
THIOTHIAMINE is used as a research tool in neurochemical studies to investigate the mechanisms underlying the synthesis and regulation of GABA. This can help researchers gain insights into the complex interactions between neurotransmitters and their role in brain function, ultimately contributing to the development of novel therapeutic strategies for neurological conditions.
Used in Quality Control of Thiamine:
THIOTHIAMINE is used as a reference compound in the quality control and purity assessment of Thiamine (T344185). By monitoring the presence and concentration of THIOTHIAMINE, manufacturers can ensure the quality and safety of Thiamine products, which are essential for various applications in the pharmaceutical, dietary supplement, and animal feed industries.
Check Digit Verification of cas no
The CAS Registry Mumber 299-35-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 299-35:
(5*2)+(4*9)+(3*9)+(2*3)+(1*5)=84
84 % 10 = 4
So 299-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N4OS2/c1-7-10(3-4-17)19-12(18)16(7)6-9-5-14-8(2)15-11(9)13/h5,17H,3-4,6H2,1-2H3,(H2,13,14,15)
299-35-4Relevant articles and documents
Secondary Deuterium Kinetic Isotope Effects in the Cleavage of Thiamin and N-Methylthiaminium Ion: First Evidence To Identify the Rate-Limiting Step
Uray, Georg,Celotto, Claude,Ibovnik, Anton,Zoltewicz, John A.
, p. 3941 - 3945 (1989)
Thiamin and 1'-methylthiaminum ion deuterated at the 6'- and N-methylene positions were cleaved by sulfite ion in aqueous phosphate at 25 deg C.Observed secondary kinetic isotope effects (standard deviation of the ratio) were inverse for the 6'-position, 0.95 (0.09) and 0.95 (0.03), respectively, and normal for the N-methylene group., 1.08 (0.09) and 1.10 (0.03), respectively.These results confirm the multistep mechanism first proposed by us (J.Am.Chem.Soc. 1977, 99, 3134).They prove for the first time that sulfite ion adds to the 6'-position and that fragmentation of the CH2-thiazole bond in the resultant adduct contributes to the rate in the multistep mechanism.
THIAMIN YLIDE: iSOLATION AND IDENTIFICATION
Sugimoto, Hirohiko,Hirai, Kentaro
, p. 883 - 886 (2007/10/02)
The action ot two equivalents of NaOEt on thiamin hydrochloride in EtOH gives a neutral compound.Spectroscopic data and its chemical behavior indicated that the compound is thiamin ylide 1.The chemical behaviors of 1 are entirely consistent with those of in situ generated thiamin ylide.