299-95-6 Usage
Originator
Isonorin,Smith, Miller and Patch,US,1949
Uses
Bronchodilator.
Manufacturing Process
As described in US Patent 2,308,232, 100 g 3,4-dihydroxy-ω-
chloroacetophenone, 200 cc ethyl alcohol and 200 cc of about 50% aqueous
isopropylamine solution are boiled during 3 hours on the water bath with the
use of a reflux condenser, whereupon neutralizing with diluted sulfuric acid is
carried out and the sulfate, obtained upon cooling, from alcohol of 50% is
recrystallized; its MP is 245°C.21 g 3,4-dihydroxy-ω-isopropylaminoacetophenone sulfate are hydrogenated
with 50 cc methyl alcohol and 50 cc water, 0.5 g carbon and 3 cc palladium
chloride solution of 2%. After 2 hours the hydrogen absorption comes to a
standstill, after the theoretical quantity of hydrogen has been absorbed. After
concentrating, the isopropylaminomethyl-(3,4-dihydroxyphenyl)carbinolsulfate
crystallizes out. It has a MP of 180°C after refining.
Brand name
Medihaler-ISO (3M Pharmaceuticals).
Therapeutic Function
Bronchodilator
Check Digit Verification of cas no
The CAS Registry Mumber 299-95-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 299-95:
(5*2)+(4*9)+(3*9)+(2*9)+(1*5)=96
96 % 10 = 6
So 299-95-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H17NO3.H2O4S/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;1-5(2,3)4/h3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4)
299-95-6Relevant articles and documents
Method for preparing isoproterenol sulfate dihydrate
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Paragraph 0021, (2017/09/01)
The invention relates to a method for preparing isoproterenol sulfate dihydrate. The method comprises the following steps: (1) preparation of 2-bromo-1-(3, 4-dihydroxy phenyl)-ethanone; (2) preparation of isoproterenol ketone hydrochloride; and (3) preparation of isoproterenol sulfate dihydrate. The method disclosed by the invention adopts a reaction system of bromoacetyl bromide and aluminium chloride instead of a reaction system of monochloro acetic acid and phosphorus oxychloride, so that the method has the advantages that the environmental protection cost is reduced; the reaction yield is increased; the industrial production is benefited; the reaction condition is mild; the catalyst quantity is little; and the process is simple. Compared with conventional synthetic processes, the method disclosed by the invention has obvious economic benefit and environmental benefit.