299165-10-9

Basic information

• Product Name: ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester
• Synonyms: ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester
• CAS NO: 299165-10-9
• Molecular Weight: 366.364
• Mol File: 299165-10-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester(299165-10-9)
• EPA Substance Registry System: ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester(299165-10-9)

Safety Data

• Hazardous Substances Data: 299165-10-9(Hazardous Substances Data)

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 105-36-2 ethyl bromoacetate 
• 98-86-2 acetophenone 
• 104960-49-8 2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 1581726-08-0 C₁₇H₁₂F₃NO₂S 
• 1581726-22-8 C₁₅H₈F₃NO₂S 
• 104960-56-7 3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine 
• 827010-27-5 C₁₇H₁₄F₃N₃OS 
• 400863-50-5 3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridine-2-carboxylic acid diethylamide 
• 400863-51-6 (3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone 
• 1581726-24-0 C₂₄H₂₅F₃N₄O₃S 
• 1581726-25-1 C₁₉H₁₇F₃N₄OS 
• 1581726-26-2 C₂₀H₁₆F₃N₃O₂S 
• 352024-84-1 C₂₀H₁₈F₃N₃OS 
• 827008-47-9 (3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone 
• 1581726-27-3 C₁₉H₁₆F₃N₃OS₂ 
• 1581726-28-4 C₂₀H₁₈F₃N₃OS 
• 1581726-29-5 3-amino-N-benzyl-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide 

Relevant articles and documents

Synthesis of Novel Trifluoromethyl Group Containing Pyrido Furo/Thieno Pyrimidinone Derivatives and Their Anticancer Activity

A series of novel trifluoromethyl group containing pyridofuro/thieno pyrimidinone derivatives 5a–p were prepared starting from 2-oxo/thioxo-6-phenyl/thien-2-yl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 1 compound on reaction with bromoethylac

2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and preparing method and application thereof

The invention belongs to the field of chemical pharmaceuticals, and particularly relates to a 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and a preparing method and application thereof. The structure of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative is shown in the formula I. A compound of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative has the good HCV inhibitory effect, and meanwhile shows the low cytotoxicity, and a new method is provided for development of an anti-HCV inhibitor. The general formula is defined in the description.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.