29976-56-5

Basic information

• Product Name: 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE
• Synonyms: 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE;3,5-DIBROMO-2,4,6-COLLIDINE;PYRIDINE,3,5-DIBROMO-2,4,6-TRIMETHYL;3,5-Dibromo-2,4,6-Trimethylpyridine Hydrochloride(WXC04385)
• CAS NO: 29976-56-5
• Molecular Formula: C₈H₉Br₂N
• Molecular Weight: 278.97
• Product Categories: Pyridines
• Mol File: 29976-56-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 265°Cat760mmHg
• Flash Point: 114.1°C
• Appearance: /
• Density: 1.702g/cm³
• Vapor Pressure: 0.0154mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE(29976-56-5)
• EPA Substance Registry System: 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE(29976-56-5)

Safety Data

• Hazardous Substances Data: 29976-56-5(Hazardous Substances Data)

Usage

General Description

3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE is a chemical compound with the molecular formula C8H10Br2N2. It is a derivative of pyridine with three methyl groups and two bromine atoms attached to the aromatic ring. 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE is used in various organic synthesis reactions and as a building block for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. It is a yellow crystalline solid with a strong odor and is considered to be mildly toxic. 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE is also known to have potential environmental hazards and should be handled with caution.

InChI:InChI=1/C8H9Br2N/c1-4-7(9)5(2)11-6(3)8(4)10/h1-3H3

Upstream product

• 108-75-8 2,4,6-trimethyl-pyridine 
• 7732-18-5 water 
• 7726-95-6 bromine 

Relevant articles and documents

Introducing a Cantellation Strategy for the Design of Mesoporous Zeolite-like Metal-Organic Frameworks: Zr-sod-ZMOFs as a Case Study

Herein we report novel mesoporous zirconium-based metal-organic frameworks (MOFs) with zeolitic sodalite (sod) topology. Zr-sod-ZMOF-1 and -2 are constructed based on a novel cantellation design strategy. Distinctly, organic linkers are judiciously designed in order to promote the deployment of the 12-coordinated Zr hexanuclear molecular building block (MBB) as a tetrahedral secondary building unit, a prerequisite for zeolite-like nets. The resultant Zr-sod-ZMOFs exhibit mesopores with a diameter up to ≈43 ?, while the pore volume of 1.98 cm3·g-1 measured for Zr-sod-ZMOF-1 is the highest reported experimental value for zeolite-like MOFs based on MBBs as tetrahedral nodes.

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents

Recent studies have indicated that the CCR5 chemokine receptor may be a potential target for treating prostate cancer. Thus, development of CCR5 antagonists may provide novel prostate cancer therapy. Anibamine, a novel pyridine quaternary alkaloid isolated from Aniba sp., was found to effectively compete with 125I-gp120 in binding to the chemokine receptor CCR5, with an IC50 = 1 μM. Anibamine is the first natural product reported as a CCR5 antagonist, and thus provides a novel structural skeleton unique from other lead compounds that have generally been identified from high-throughput screening efforts. In order to refine the lead compound's structure and improve the therapeutic index of anibamine derivatives as potential anti prostate cancer agents, the approach of "deconstruction- reconstruction-elaboration" was applied in the structure-activity relationship studies of this work. Here, we report the design, syntheses and anti prostate cancer activities of anibamine and 17 analogues. The results from the in vitro and in vivo studies described here show that this class of compounds has potential to provide novel leads as anti prostate cancer agents.