30030-90-1

Basic information

• Product Name: 3-TRICHLOROACETYLINDOLE
• Synonyms: 3-TRICHLOROACETYLINDOLE;2,2,2-TRICHLORO-1-(1H-INDOL-3-YL)-ETHANONE;3-Trichloroacetyl-1H-indole;Ketone indol-3-yl trichloromethyl;3-trichloroacetyllindole;2,2,2-trichloro-1-(1H-indol-3-yl)ethan-1-one
• CAS NO: 30030-90-1
• Molecular Formula: C₁₀H₆Cl₃NO
• Molecular Weight: 262.52
• Product Categories: Indoles and derivatives
• Mol File: 30030-90-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 235-237℃ (DEC.)
• Boiling Point: 384.6 °C at 760 mmHg
• Flash Point: 186.4 °C
• Appearance: /
• Density: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-TRICHLOROACETYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRICHLOROACETYLINDOLE(30030-90-1)
• EPA Substance Registry System: 3-TRICHLOROACETYLINDOLE(30030-90-1)

Safety Data

• Hazardous Substances Data: 30030-90-1(Hazardous Substances Data)

Usage

General Description

3-Trichloroacetylindole is a chemical compound that belongs to the class of indole derivatives. It is a derivative of indole with three chlorine atoms attached to the acetyl group. 3-TRICHLOROACETYLINDOLE has various applications in organic synthesis and medicinal chemistry. It has been studied for its potential in drug discovery and development, particularly in the field of oncology and neuroscience. Its unique structure and properties make it a valuable building block for the synthesis of diverse molecules with potential biological activity. As a result, 3-Trichloroacetylindole has garnered interest in the scientific community and holds promise for further research and development in the future.

Upstream product

• 1477-50-5 Indole-2-carboxylic acid 
• 76-03-9 trichloroacetic acid 
• 120-72-9 indole 
• 76-02-8 trifluoroacetyl chloride 
• 4124-31-6 trichloroacetic acid anhydride 
• 545-06-2 trichloroacetonitrile 

Downstream Products

• 776-41-0 indole-3-carboxylic acid ethyl ester 
• 1333169-31-5 (R)-2,2,2-trichloro-1-(1-(2-bromophenyl)ethyl-1H-indol-3-yl)ethan-1-one 
• 1333169-30-4 (R)-ethyl 1-(1-(2-bromophenyl)ethyl)-1H-indole-3-carboxylate 
• 15317-58-5 1H-indole-3-carboxylic acid hydrazide 
• 771-50-6 1H-indole-3-carboxylic acid 

Relevant articles and documents

Amination/Cyclization Cascade by Acid-Catalyzed Activation of Indolenine for the One-Pot Synthesis of Phaitanthrin E

We have developed a concise one-pot synthesis of phaitanthrin E derivatives, where simple starting materials undergo an acid-catalyzed intermolecular amination/intramolecular cyclization cascade.

A new methodology for functionalization at the 3-position of indoles by a combination of boron lewis acid with nitriles

We discovered that a reagent comprising a combination of PhBCl2 and nitriles was useful for syntheses of both 3-acylindoles and 1-(1H-indol-3-yl)alkylamine from indoles. The reaction proceeded selectively at the 3-position of indoles providing 3-acylindoles in moderate to high yields on treatment with the above reagent. Furthermore, the reaction provided the corresponding amine products in moderate to high yields after the intermediate imine was reduced by NaBH3CN. These reactions proceeded under mild conditions and are applicable to the formation of indoles functionalized at the 3-position.

1,3,4,16B-TETRAHYDRO-2H,10H-INDOLO[2,1-C]PYRAZINO-[1,2-A][1,4]BENZODIAZEPINES USEFUL AS SEROTONIN-2 RECEPTOR ANTAGONISTS

The invention relates to 1,3,4,16b-tetrahydro-2H,10H-indolo 2, 1-c!pyrazino 1,2-a! 1,4!benzodiazepine derivatives of the formula I, STR1 wherein R 1 is hydrogen, lower alkyl, C 3-7-alkenyl, C. sub.3-7-alkynyl, 3 to 7 ring-membered cycloalkyl, C 2-7-alkyl