30038-94-9

Basic information

• Product Name: 1-BROMO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER
• Synonyms: 1-BROMO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER;ETHYL 1-BROMOCYCLOPENTANECARBOXYLATE
• CAS NO: 30038-94-9
• Molecular Formula: C₈H₁₃BrO₂
• Molecular Weight: 221.09
• Mol File: 30038-94-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 219.7±23.0 °C(Predicted)
• Appearance: /
• Density: 1.420±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-BROMO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER(30038-94-9)
• EPA Substance Registry System: 1-BROMO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER(30038-94-9)

Safety Data

• Hazardous Substances Data: 30038-94-9(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Uses

a. Intermediate in the synthesis of pharmaceuticals and agrochemicals
b. Reagent in organic chemistry reactions
c. Formation of C-C and C-O bonds

Hazardous properties

a. Harmful if swallowed
b. Harmful if inhaled
c. Harmful if in contact with skin

Safety measures

Proper precautions and handling required

Upstream product

• 37891-70-6 2-cyclopentylidene-[1,3]dithiane 
• 64-17-5 ethanol 
• 5453-85-0 ethyl cyclopentanecarboxylate 
• 56447-24-6 1-bromo-1-cyclopentanecarboxylic acid 
• 3400-45-1 cyclopentanecarboxylic acid 

Downstream Products

• 388077-77-8 1-(5-benzyl-2-tetrazolyl)-1-cyclopentanecarboxylic acid 
• 328236-05-1 (S)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 328236-07-3 (R)-3-Benzylsulfanyl-2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-propionic acid methyl ester 
• 328236-09-5 2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 328235-94-5 (R)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-phenyl-propionic acid methyl ester 
• 328235-95-6 (S)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-phenyl-propionic acid methyl ester 
• 328235-93-4 (S)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-methyl-butyric acid methyl ester 
• 328235-92-3 (R)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-methyl-butyric acid methyl ester 

Relevant articles and documents

2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11β- hydroxysteroid dehydrogenase type 1 inhibitors: Enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has attracted considerable attention during the past few years as a potential target for the treatment of diseases associated with metabolic syndrome. In our ongoing work on 11β-HSD1 inhibitors, a series of new 2-amino-1,3-thiazol-4(5H)-ones were explored. By inserting various cycloalkylamines at the 2-position and alkyl groups or spirocycloalkyl groups at the 5-position of the thiazolone, several potent 11β-HSD1 inhibitors were identified. An X-ray cocrystal structure of human 11β-HSD1 with compound 6d (Ki = 28 nM) revealed a large lipophilic pocket accessible by substitution off the 2-position of the thiazolone. To increase potency, analogues were prepared with larger lipophilic groups at this position. One of these compounds, the 3-noradamantyl analogue 8b, was a potent inhibitor of human 11β-HSD1 (Ki = 3 nM) and also inhibited 11β-HSD1 activity in lean C57Bl/6 mice when evaluated in an ex vivo adipose and liver cortisone to cortisol conversion assay.

7 2-(Aminocarbonylalkoxyimino)acetamido! derivatives of cephalosporin

Cephalosporin antibiotics in which the 7β-acylamido group has the structure STR1 (WHERE R is phenyl, thienyl or furyl; Ra and Rb are each selected from hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C2-5 alkoxycarbonyl, aminocarbonyl, N-substituted aminocarbonyl and cyano, or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene or cycloalkenylidene group; Rc is hydrogen or C1-4 alkyl; and m and n are each 0 or 1 such that the sum of m and n is 0 or 1) exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce β-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly good activity against Proteus organisms including indole positive strains and, especially when both Ra and Rb are other than hydrogen, against Pseudomonas organisms.