30062-37-4

Basic information

• Product Name: indolizino[1,2-b]quinolin-9(11H)-one
• CAS NO: 30062-37-4
• Molecular Formula: C₁₅H₁₀N₂O
• Molecular Weight: 234.2527
• Mol File: 30062-37-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 564.4°C at 760 mmHg
• Flash Point: 295.1°C
• Density: 1.39g/cm³
• Vapor Pressure: 9.23E-13mmHg at 25°C
• Refractive Index: 1.767
• CAS DataBase Reference: indolizino[1,2-b]quinolin-9(11H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: indolizino[1,2-b]quinolin-9(11H)-one(30062-37-4)
• EPA Substance Registry System: indolizino[1,2-b]quinolin-9(11H)-one(30062-37-4)

Safety Data

• Hazardous Substances Data: 30062-37-4(Hazardous Substances Data)

Usage

General Description

Indolizino[1,2-b]quinolin-9(11H)-one is a chemical compound with a unique molecular structure. It belongs to the class of indole alkaloids and is known for its diverse pharmacological properties, including anti-inflammatory, anti-cancer, and anti-bacterial activities. The compound has also been studied for its potential use in drug development and medicinal chemistry. Its distinct chemical structure and biological activities make it a subject of interest for researchers in the fields of pharmaceuticals and medicinal chemistry. Additionally, its potential applications in various therapeutic areas make it a promising candidate for further study and development.

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Relevant articles and documents

Combined directed ortho metalation/cross-coupling strategies: Synthesis of the tetracyclic A/B/C/D ring core of the antitumor agent camptothecin

A convergent synthesis of the A/B/C/D ring fragment 5 of camptothecin using a combination of directed ortho metalation and Negishi cross-coupling is described. The key features of the synthetic sequence are an anionic ortho-Fries rearrangement (10 → 12), a Negishi cross-coupling (7 → 6), and a terminal modified von Braun reaction (16 → 5) that leads to tetracyclic derivative 5 in 7 steps and 11% overall yield.

A synthetic camptothecin compound in 5-6 method of and ring structure (by machine translation)

The present invention discloses a synthetic camptothecin compound in the 5 [...] 6 method of and ring structure, the method is that the conjugated structure of formula II occurs in the solvent alkene alkyne ester series cyclization reaction in the molecule, thus the system results in the type shown in I of the 5 [...] 6 and ring structure, the specific equation is: In the formula: R 1 and R 2 are respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic group; or, R 1 and R 2 together form a saturated or unsaturated carbocyclic or heterocyclic; R 3 and R 4 are respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic group; or, R 3 and R 4 together form a saturated or unsaturated carbocyclic or heterocyclic rings; selected from R C 1-C 4 alkyl; P is amino protecting group. The stated method of this invention has the advantages of simple operation, safety and environmental protection, low production cost, high yield, is suitable for large-scale production, and the like, to promote such compounds in the medical field with the extensive application of an important value. (by machine translation)

Traceless solid-phase synthesis of mappicine ketone library via multiple chemoselective palladium-catalyzed reactions on benzenesulfonate linker

We report here a solid-phase synthesis of a library of mappicine ketone, a leading antiviral compound with activity against herpes viruses and human cytomegalovirus. The synthesis is based on multiple chemoselective palladium-catalyzed reactions involving