300658-92-8Relevant articles and documents
3-amin3-arylpropan-1-ol compounds, their preparation and use
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, (2008/06/13)
3-amino-3-arylpropan-1-ol compounds of formula I: R1and R2independently denoting C1-6alkyl, or together denoting a (CH2)2-6ring optionally substituted by phenyl, R3denoting C3-6alkyl, C3-6cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6to R8, or a substituted C1-3alkylphenyl of formula XII: ?R4and R5independently denoting C1-6alkyl, C3-6cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6or CH2CH2OCH2CH2ring, R6to R8independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4ring, R14denoting C1-6alkyl, phenyl, benzyl, or phenethyl, R15and R16independently denoting H, C1-6alkyl, phenyl, benzyl or phenethyl, and A denoting optionally substituted aryl optionally containing heteroatoms, or a diastereomer or enantiomer or pharmaceutically acceptable salt thereof, and their preparation and use in pharmaceutical compositions.
