300827-87-6 Usage
Description
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride is a complex organic compound with a unique chemical structure. It is characterized by the presence of a phenol group, a cyclohexyl ring, and a dimethylamino functional group. 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride has the potential for various applications due to its specific chemical properties and interactions with other molecules.
Uses
Used in Pharmaceutical Industry:
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride is used as an active pharmaceutical ingredient for the development of medications targeting specific medical conditions. Its unique structure allows it to interact with biological targets, such as receptors or enzymes, to elicit desired therapeutic effects.
Used in Antidepressant Development:
In the field of antidepressant research, 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride is used as a selective serotonin noradrenaline reuptake inhibitor (SNRI). It works by blocking the reuptake of serotonin and noradrenaline in the brain, thereby increasing their levels and improving mood and reducing symptoms of depression.
Used in Environmental Research:
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride has been utilized in studies to evaluate its potential effects on neuronal gene expression when present in drinking water at environmental concentrations. This research helps to understand the compound's impact on human health and the environment, contributing to the development of safety guidelines and regulations.
Used in Drug Delivery Systems:
Similar to gallotannin, 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride can also be employed in the development of novel drug delivery systems. These systems aim to improve the compound's delivery, bioavailability, and therapeutic outcomes by using various organic and metallic nanoparticles as carriers.
Biochem/physiol Actions
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
Check Digit Verification of cas no
The CAS Registry Mumber 300827-87-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,2 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 300827-87:
(8*3)+(7*0)+(6*0)+(5*8)+(4*2)+(3*7)+(2*8)+(1*7)=116
116 % 10 = 6
So 300827-87-6 is a valid CAS Registry Number.
300827-87-6Relevant articles and documents
A hydrochloride desvenlafaxine method for the preparation of
-
Paragraph 0015-0032, (2020/05/05)
The invention relates to a preparation method of desvenlafaxine hydrochloride. The preparation method comprises the following steps: adding venlafaxine hydrochloride into methanesulfonic acid, and adding a demethylation reagent methionine. The preparation method provided by the invention is green and environment-friendly while the temperature is not high, few byproducts are generated and the product quality is good; and moreover, the yield is over 88%, and the purity reaches 99.9%.
PROCESS FOR THE PREPARATION OF DESVENLAFAXINE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF
-
Page/Page column 9-10, (2010/08/04)
The present invention relates to a process for the preparation of desvenlafaxine or a pharmaceutically acceptable acid addition salt thereof, based on the demethylation of venlafaxine by the use of alkyl aluminium or alkyl aluminium hydride compounds, particularly TIBA and DIBAL.
