300833-95-8 Usage
Description
GSA 10 is a quinolinecarboxamide derivative that acts as a novel small-molecule positive modulator of Smoothened (SMO), a cell surface receptor involved in hedgehog signaling to regulate gene expression through the Gli transcription factors. It promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts and has potential therapeutic interests in regenerative medicine.
Uses
Used in Regenerative Medicine:
GSA 10 is used as a positive modulator of SMO for promoting the differentiation of multipotent mesenchymal progenitor cells into osteoblasts, with an EC50 of 1.2 μM. This makes it a promising candidate for applications in regenerative medicine, particularly in bone tissue repair and regeneration.
Used in Drug Discovery and Development:
GSA 10 is used as a research tool for characterizing a novel SMO active site, as it does not recognize the classic cyclopamine binding site like other SMO agonists. This unique property allows researchers to investigate the structure and function of SMO, potentially leading to the development of new drugs targeting this receptor for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 300833-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,3 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 300833-95:
(8*3)+(7*0)+(6*0)+(5*8)+(4*3)+(3*3)+(2*9)+(1*5)=108
108 % 10 = 8
So 300833-95-8 is a valid CAS Registry Number.
300833-95-8Relevant articles and documents
Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives
Manetti, Fabrizio,Petricci, Elena,Gabrielli, Annalisa,Mann, Andrè,Faure, Hélène,Gorojankina, Tatiana,Brasseur, Laurent,Hoch, Lucile,Ruat, Martial,Taddei, Maurizio
, p. 747 - 757 (2016/07/21)
Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.
