300843-36-1 Usage
Chemical class
Phthalazine derivatives It belongs to a group of chemical compounds that contain a phthalazine ring.
Molecular structure
Organic molecule with a phthalazine ring and a chlorine atom The molecule consists of a phthalazine ring (a fused six-membered nitrogen-containing ring) with a chlorine atom attached at the first carbon position.
Salt form
Hydrochloride The compound is commonly used in its hydrochloride salt form, which enhances its solubility and stability.
Pharmaceutical research
Potential biological activities 1-Chlorophthalazine hydrochloride has been studied for its various biological activities, making it a valuable compound in drug development.
Anticonvulsant properties
Used to treat seizures The compound has demonstrated potential in reducing the frequency and severity of seizures in certain conditions.
Antioxidant properties
Neutralizes free radicals It has the ability to neutralize harmful free radicals, which can cause cellular damage and contribute to various diseases.
Anticancer properties
Potential in cancer treatment Research has shown that 1-chlorophthalazine hydrochloride may have potential applications in the treatment of certain types of cancer.
Building block
Synthesis of pharmaceutical agents and chemicals The compound serves as a starting material or intermediate in the synthesis of various pharmaceuticals and chemicals.
Applications
Medical and chemical industries 1-Chlorophthalazine hydrochloride has diverse potential applications in both the medical and chemical industries, making it a valuable compound for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 300843-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,4 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 300843-36:
(8*3)+(7*0)+(6*0)+(5*8)+(4*4)+(3*3)+(2*3)+(1*6)=101
101 % 10 = 1
So 300843-36-1 is a valid CAS Registry Number.
300843-36-1Relevant articles and documents
Structure-metabolism relationships in human-AOX: Chemical insights from a large database of aza-aromatic and amide compounds
Lepri, Susan,Ceccarelli, Martina,Milani, Nicolò,Tortorella, Sara,Cucco, Andrea,Valeri, Aurora,Goracci, Laura,Brink, Andreas,Cruciani, Gabriele
, p. E3178 - E3187 (2017/04/24)
Aldehyde oxidase (AOX) is a metabolic enzyme catalyzing the oxidation of aldehyde and aza-aromatic compounds and the hydrolysis of amides, moieties frequently shared by the majority of drugs. Despite its key role in human metabolism, to date only fragmentary information about the chemical features responsible for AOX susceptibility are reported and only "very local" structure-metabolism relationships based on a small number of similar compounds have been developed. This study reports a more comprehensive coverage of the chemical space of structures with a high risk of AOX phase I metabolism in humans. More than 270 compounds were studied to identify the site of metabolism and themetabolite(s). Both electronic [supported by density functional theory (DFT) calculations] and exposure effects were considered when rationalizing the structure-metabolism relationship.
Phthalazine derivatives for treating inflammatory diseases
-
, (2008/06/13)
The invention relates to the treatment of an inflammatory disease, especially an inflammatory rheumatoid or rheumatic disease, and/or pain with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, wherein r is 0 to 2, n is 0 to
