30104-32-6Relevant articles and documents
Synthesis of glycosylamines: Identification and quantification of side products
Campa, Cristiana,Donati, Ivan,Vetere, Amedeo,Gamini, Amelia,Paoletti, Sergio
, p. 263 - 273 (2001)
The synthesis of some glycosylamines (1-amino-1-deoxy-D-glucose, 1-amino-1-deoxy- D-galactose and 1-amino-1-deoxylactose) was carried out by treatment of the corresponding reducing sugars with ammonium hydrogencarbonate in concentrated ammonia. The reaction mixture was first analyzed by capillary electrophoresis with indirect absorbance detection and high performance anion-exchange chromatography with pulsed amperometric detection. Beside glycosylcarbamate, a known reaction by-product, fructose and lactulose were detected during the synthesis of 1-amino-1-deoxyglucose and 1-amino-1-deoxylactose, respectively. Quantification of glycosylamines was carried out by micellar electrokinetic chromatography with UV detection of their 9-fluorenylmethyloxycarbonyl (Fmoc) derivatives; lactulosylamine was thus detected in the synthesis mixture of 1-amino-1-deoxylactose. The Fmoc-glycosylamines were easily purified from the other components of the crude synthesis mixtures.
7-nitrobenzo-2-oxa-1, 3-diazole deoxyglucosamine as well as preparation method and application of 7-nitrobenzo-2-oxa-1, 3-diazole deoxyglucosamine
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Paragraph 0030; 0032-0034, (2020/07/06)
The invention discloses following three 7-nitrobenzo-2-oxa-1, 3-diazole (NBD) deoxyglucosamine (NBDG) compounds as well as pharmaceutically acceptable salts, a preparation method and an application thereof. The key point of the invention is that the following compounds are deoxyglucose analogues with fluorescein, are used for monitoring glucose uptake of living cell tissues, are one of indexes forjudging cell viability, are used for monitoring local tumor formation, and can also be used as high-sensitivity fluorescent markers in a glucose transport detection method.
