301222-66-2

Basic information

• Product Name: 2-AMINO-5-FLUORO-4-PICOLINE
• Synonyms: 2-AMINO-5-FLUORO-4-PICOLINE;2-AMINO-4-METHYL-5-FLUOROPYRIDINE;2-Pyridinamine,5-fluoro-4-methyl-(9CI);2-AMINO-5-FLUORO-4-METHYLPYRIDINE;5-fluoro-4-methylpyridin-2-amine;5-Fluoro-4-methyl-2-pyridinamine
• CAS NO: 301222-66-2
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.13
• Product Categories: AMINEPRIMARY;PYRIDINE;Pyridine series;Pyridines;Boronic Acid
• Mol File: 301222-66-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 145.0 to 149.0 °C
• Boiling Point: 219.271 °C at 760 mmHg
• Flash Point: 86.412 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 0.12mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.24±0.24(Predicted)
• CAS DataBase Reference: 2-AMINO-5-FLUORO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-FLUORO-4-PICOLINE(301222-66-2)
• EPA Substance Registry System: 2-AMINO-5-FLUORO-4-PICOLINE(301222-66-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 301222-66-2(Hazardous Substances Data)

Usage

General Description

2-Amino-5-Fluoro-4-Picoline, also known as 5-Fluoro-2-Aminopicoline, is a type of organic compound with chemical formula C6H6FN3. This chemical compound belongs to the pyridines and derivatives class of substances, characterized by a ring structure containing a nitrogen atom with substituted amino and fluorine groups. 2-Amino-5-Fluoro-4-Picoline is commonly used in the production of other chemical substances as intermediate. It's a significant component in pharmaceuticals synthesis and organic synthesis projects. It's noteworthy that like many other chemicals, appropriate safety measures are necessary while handling as it can cause eye, skin, and respiratory irritation.

InChI:InChI=1/C6H7FN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 695-34-1 2-Amino-4-methylpyridine 
• 90765-02-9 N-(4-methyl-5-nitropyridin-2-yl) acetamide 
• 475060-18-5 N₁-(5-amino-4-methyl-pyridin-2-yl)acetamide 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 475060-21-0 N₁-(5-fluoro-4-methyl-pyridin-2-yl)acetamide 

Downstream Products

• 1609531-37-4 C₂₁H₂₀FN₅O₄ 
• 917918-86-6 2-amino-3-nitro-4-methyl-5-fluoropyridine 
• 1628184-28-0 5-fluoro-4-methyl-2-nitropyridine 
• 1609530-14-4 6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide 

Relevant articles and documents

Selective Fluorination of 4-Substituted 2-Aminopyridines and Pyridin-2(1 H)-ones in Aqueous Solution

Fluorination of 2-aminopyridines and pyridin-2(1H)-ones in the presence of Selectfluor, water, and chloroform under mild conditions has been realized. This method gives fluorinated pyridines in good to high yields with high regioselectivities. The electro

Drug efflux pump inhibitor

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)— (R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.