301301-14-4

Basic information

• Product Name: (R)-2-Amino-3-((3S,3aS,6aR,9aR,9bS)-6,9-dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-propionic acid
• Synonyms: (R)-2-Amino-3-((3S,3aS,6aR,9aR,9bS)-6,9-dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-propionic acid
• CAS NO: 301301-14-4
• Molecular Weight: 351.467
• Mol File: 301301-14-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-Amino-3-((3S,3aS,6aR,9aR,9bS)-6,9-dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Amino-3-((3S,3aS,6aR,9aR,9bS)-6,9-dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-propionic acid(301301-14-4)
• EPA Substance Registry System: (R)-2-Amino-3-((3S,3aS,6aR,9aR,9bS)-6,9-dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethylsulfanyl)-propionic acid(301301-14-4)

Safety Data

• Hazardous Substances Data: 301301-14-4(Hazardous Substances Data)

Upstream product

• 52-90-4 L-Cysteine 
• 74299-48-2 dehydrocostus lactone 

Downstream Products

• 74299-48-2 dehydrocostus lactone 

Relevant articles and documents

Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa

From the methanolic extract of the dried roots of Saussurea lappa Clarke, Saussureae Radix, five amino acid-sesquiterpene conjugates, saussureamines A, B, C, D and E, were isolated together with a lignan glycoside, (-)-massoniresinol 4-O-β-D-glucopyranoside. Their stereostructures were determined on the basis of chemical and physicochemical evidence. In addition, saussureamines and the related amino acid-sesquiterpene conjugates were synthesized using a Michael type addition reaction of amino acid to the α-methylene-γ-lactone moiety of sesquiterpenes. Saussureamines A, B and C, costunolide and dehydrocostus lactone showed a gastroprotective effect on acidified ethanol-induced gastric mucosal lesions in rats. Saussureamines A also exhibited an inhibitory effect on gastric mucosal lesions induced by water-immersion stress in mice. (C) 2000 Elsevier Science Ltd.