301359-12-6

Basic information

• Product Name: N-(2,4-dichlorophenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2,4-dichlorophenyl)-4-methylbenzenesulfonamide
• CAS NO: 301359-12-6
• Molecular Weight: 316.208
• Mol File: 301359-12-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2,4-dichlorophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dichlorophenyl)-4-methylbenzenesulfonamide(301359-12-6)
• EPA Substance Registry System: N-(2,4-dichlorophenyl)-4-methylbenzenesulfonamide(301359-12-6)

Safety Data

• Hazardous Substances Data: 301359-12-6(Hazardous Substances Data)

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 68-34-8 phenyl toluenesulfonamide 
• 7782-50-5 chlorine 
• 6380-05-8 N-tosyl-2-chloroaniline 
• 856352-69-7 toluene-4-sulfonic acid-(2,4,N-trichloro-anilide) 

Downstream Products

• 946162-01-2 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide 
• 856352-69-7 toluene-4-sulfonic acid-(2,4,N-trichloro-anilide) 

Relevant articles and documents

One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst

Disubstituted benzo[b]furans were synthesized by ortho-selective Sonogashira coupling of dichlorophenols and terminal alkynes, followed by cyclization and Suzuki-Miyaura coupling in one pot, using a palladium-dihydroxyterphenylphosphine (Cy-DHTP) catalyst. The use of substoichiometric amounts of tetrabutylammonium chloride was effective in accelerating the Suzuki-Miyaura coupling. This protocol was also successfully applied to the one-pot synthesis of disubstituted indoles from dichloroaniline derivatives.

Efficient oxidative chlorination of aromatics on saturated sodium chloride solution

An efficient metal-free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy-to-handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical. Copyright