301533-59-5

Basic information

• Product Name: Methyl 4-butylacetamino-3-methylbenzoate
• Synonyms: Methyl 4-butylacetamino-3-methylbenzoate;4-butylacetamino-3-methylbenzoic acid methyl ester;4-Butyramide-3-Methylbenzoic Acid Methyl Ester;3-methyl-4-[(1-oxobutyl)amino]-,methyl ester;Methyl 4-butyraMido-3-Methylbenzoate;methyl 4-(N-butylacetamido)-3-methylbenzoate;methyl 4-(butanoylamino)-3-methylbenzoate
• CAS NO: 301533-59-5
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 263.33
• EINECS: 926-717-7
• Product Categories: INTERMEDIATESOF
• Mol File: 301533-59-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 397.495 °C at 760 mmHg
• Flash Point: 194.198 °C
• Appearance: /
• Density: 1.075 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 4-butylacetamino-3-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-butylacetamino-3-methylbenzoate(301533-59-5)
• EPA Substance Registry System: Methyl 4-butylacetamino-3-methylbenzoate(301533-59-5)

Safety Data

• Hazardous Substances Data: 301533-59-5(Hazardous Substances Data)

Usage

General Description

Methyl 4-butylacetamino-3-methylbenzoate is a chemical compound that belongs to the class of esters. It is derived from 4-butylacetanilide and 3-methylbenzoic acid, and is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. Methyl 4-butylacetamino-3-methylbenzoate has a wide range of applications, including its use as an analgesic and antipyretic agent. It is a white to off-white crystalline powder that is sparingly soluble in water, but soluble in organic solvents. Methyl 4-butylacetamino-3-methylbenzoate is also known by its chemical formula C15H21NO3.

InChI:InChI=1/C13H17NO3/c1-4-5-12(15)14-11-7-6-10(8-9(11)2)13(16)17-3/h6-8H,4-5H2,1-3H3,(H,14,15)

Upstream product

• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 141-75-3 butyryl chloride 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 

Downstream Products

• 152628-01-8 4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester 
• 144702-26-1 tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate 
• 144701-48-4 telmisatran 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities

A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.

Facile Synthesis of Novel Nonpeptide Angiotensin II Receptor Antagonists

A series of Losartan analogues 1-12 with different functional groups were synthesized and characterized. In comparison with the previous reports, the synthetic procedures described in this paper have been optimized as follows below: 1) preparation of aromatic amine 15 and 18 through hydrogenation by employing Raney Ni and hydrazine as catalysts in place of palladium; 2) preparation of nitro-compound 17 by using pure fuming nitric acid at -20 - -15°C; 3) alkylation of 21 with 22 or 23 in the presence of sodium hydride in place of potassium tert-butylate; 4) preparation of carboxylic acid 4 by ester cleavage rather than hydrolysis of cyano group.