30162-37-9

Basic information

• Product Name: 3-PYRIDYLTHIOUREA
• Synonyms: 3-PYRIDYLTHIOUREA;1-PYRIDIN-3-YLTHIOUREA;1-(3-PYRIDYL)-2-THIOUREA;N-PYRIDIN-3-YLTHIOUREA;PYRIDIN-3-YL-THIOUREA;3-PYRIDYLTHIOUREA, 98+%;Pyridin-2-yl-thiourea;N-(3-Pyridinyl)thiourea
• CAS NO: 30162-37-9
• Molecular Formula: C₆H₇N₃S
• Molecular Weight: 153.2
• EINECS: 250-075-0
• Mol File: 30162-37-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 159 °C
• Boiling Point: 298.7 °C at 760 mmHg
• Flash Point: 134.4 °C
• Appearance: /
• Density: 1.382 g/cm³
• Vapor Pressure: 0.00125mmHg at 25°C
• Refractive Index: 1.742
• PKA: 12.07±0.70(Predicted)
• BRN: 472146
• CAS DataBase Reference: 3-PYRIDYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDYLTHIOUREA(30162-37-9)
• EPA Substance Registry System: 3-PYRIDYLTHIOUREA(30162-37-9)

Safety Data

• Statements: 22-36/37/38-25
• Safety Statements: 22-36/37-45-26
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 30162-37-9(Hazardous Substances Data)

Usage

General Description

3-Pyridylthiourea is a chemical compound with the molecular formula C7H8N2S. It is a white crystalline solid that is soluble in water and organic solvents. 3-PYRIDYLTHIOUREA is known to have various biological activities, including antifungal and antibacterial properties. It has been studied for its potential applications in pharmacology and medicinal chemistry for the treatment of various diseases. Additionally, 3-pyridylthiourea is also used in the synthesis of other organic compounds due to its unique reactivity and ability to participate in various chemical reactions.

InChI:InChI=1/C6H7N3S/c7-6(10)9-5-2-1-3-8-4-5/h1-4H,(H3,7,9,10)

Upstream product

• 30162-36-8 N-(pyridin-3-ylcarbamothioyl)benzamide 
• 462-08-8 pyridin-3-ylamine 
• 1147550-11-5 ammonium thiocyanate 
• 13140-69-7 1-phenyl-3-(pyridin-3-yl)thiourea 
• 52054-85-0 methyl pyridin-3-ylcarbamodithioate 

Downstream Products

• 30162-42-6 2-(3-Pyridyl)amino-4-(3-pyridyl)thiazol 
• 30162-43-7 2-(3-Pyridyl)amino-4-(4-pyridyl)thiazol 
• 79571-73-6 4-(3,4-Dihydroxyphenyl)-2-(3-pyridylamino)thiazole hydrochloride 
• 79571-61-2 4-(2,4,5-Trichlorophenyl)-2-(3-pyridylamino)thiazole 
• 927901-21-1 N-(2-methoxybenzyl)-N'-pyridin-3-yl-guanidine acetate 
• 927901-23-3 3-({imino[(2-methoxybenzyl)amino]methyl}amino)-1-methylpyridinium acetate 
• 256471-41-7 C₁₄H₁₀FN₃S 
• 1269603-79-3 (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(pyridyl-3)amino]imidazoline 

Relevant articles and documents

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

NOVEL ANTIPRION COMPOUNDS

Described herein are novel compositions and methods of treatment addressing diseases such as neurodegenerative diseases, including prion diseases and Alzheimer's disease.

New imidazoline/α2-adrenoceptors affecting compounds-4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies

Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline and α2-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel 4(5)-(2-aminoethyl)imidazolines and their I 1, I2, α2-adrenoceptors affinities are reported.