301836-34-0

Basic information

• Product Name: Benzonitrile, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-
• CAS NO: 301836-34-0
• Molecular Formula: C22H14N4O2
• Molecular Weight: 366.379
• Mol File: 301836-34-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(301836-34-0)
• EPA Substance Registry System: Benzonitrile, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(301836-34-0)

Safety Data

• Hazardous Substances Data: 301836-34-0(Hazardous Substances Data)

Upstream product

• 301836-33-9 2-(4-cyanophenyl)-4-(3,4-methylenedioxyphenyl)-N-1-hydroxy-5-(2-pyridyl)-imidazole 

Downstream Products

• 301836-35-1 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzoic acid 

Relevant articles and documents

Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5)

Screening of our internal compound collection for inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5) identified several hits. Optimization of the dihydropyrroloimidazole hit 2 by introduction of a 2-pyridine and 3,4-methylenedioxyphenyl group gave 7, a selective ALK5 inhibitor. With this information, optimization of the triarylimidazole hit 8 gave the selective inhibitor 14, which inhibits TGF-β1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay.