30193-56-7 Usage
Description
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester is a complex organic molecule that features a hydroxy, amine, and thioether functional groups. It is a methyl ester derivative of 2-hydroxy-3-(4''-methoxyphenyl)-propionic acid, with an additional 2'-aminophenylthio group attached. The presence of the amine group allows for bioconjugation and drug delivery applications, as it can form covalent bonds with other molecules. The thioether group contributes unique chemical and biological properties, while the methyl ester group enhances lipophilicity and potentially increases bioavailability. The intricate structure of this compound suggests it may have a range of pharmaceutical and bioconjugation applications.
Uses
Used in Pharmaceutical Applications:
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester is used as a potential drug candidate for various therapeutic applications due to its complex structure and functional groups that can be tailored for specific interactions with biological targets.
Used in Bioconjugation:
In the field of bioconjugation, (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester is used as a linking agent to covalently bind other molecules, such as drugs or imaging agents, for targeted delivery or diagnostic purposes. The amine group facilitates these covalent bonds, enhancing the compound's utility in conjugation processes.
Used in Drug Delivery Systems:
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester is utilized as a component in drug delivery systems to improve the pharmacokinetics and biodistribution of therapeutic agents. Its lipophilic nature, conferred by the methyl ester group, may enhance the compound's ability to cross biological barriers and increase its overall bioavailability.
Used in Chemical Synthesis:
In the chemical synthesis industry, (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester serves as a versatile intermediate or building block for the creation of more complex molecules with specific chemical and biological properties. Its unique functional groups make it a valuable component in the synthesis of novel compounds for research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 30193-56-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,1,9 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 30193-56:
(7*3)+(6*0)+(5*1)+(4*9)+(3*3)+(2*5)+(1*6)=87
87 % 10 = 7
So 30193-56-7 is a valid CAS Registry Number.
30193-56-7Relevant articles and documents
Preparation and purification method of diltiazem chiral isomer impurity
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, (2019/11/20)
The invention provides a method for preparing and purifying a diltiazem chiral isomer. The method comprises the steps of taking p-methoxybenzaldehyde as a starting raw material, carrying out Darzens condensation, a reaction with o-aminobenzenethiol and a cyclization reaction to prepare an intermediate, carrying out chiral column separation on the intermediate, then carrying out an alkylation and acetylation reaction separately to obtain a diltiazem chiral isomer impurity I. The method is simple to operate and short in period, and the purity of the obtained diltiazem chiral isomer impurity is high, so that a reference substance is provided for quality research and drug synthesis process research of diltiazem drugs, and the method has important significance in control and checking of the chiral purity in the pharmaceutical research of diltiazem.
Process for the recycle of a waste product of diltiazem synthesis
-
, (2008/06/13)
A process which allows the re-use of compounds of formula in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.
Optical resolution of a 1,5-benzothiazepine derivative, a synthetic intermediate of diltiazem, by preferential crystallization and diastereomeric salt formation
Yamada, Shin-Ichi,Yoshioka, Ryuzo,Shibatani, Takeji
, p. 1922 - 1927 (2007/10/03)
Practical preparation methods of an optically active intermediate of diltiazem, (+)-(2S,3S)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2- (4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one [(+)-7], have been developed by the use of physicochemical and chemical resolutions. 1) The salt of (+)-7 with 3-amino-4-hydroxy-benzenesulfonic acid (AHS), was found to exist as a conglomerate and could be reproducibly resolved into (+)-7·AHS and (-)- 7·AHS of 94-98% ee by a preferential crystallization procedure. 2) (+)- (1R)-3-Bromocamphor-9-sulfonic acid [(+)-BCS] was found to be an efficient resolving agent for (±)-7 and the diastereomeric resolution provided (+)- 7·(+)-BCS·2H2O salt in >43% yield and >97% ee by fractional crystallization. It is presumed that the crystal water of (+)-7·(+)- BCS·2H2O plays an important role in the selective crystallization during this efficient resolution.
