30235-28-0

Basic information

• Product Name: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE
• Synonyms: 2-AMINO-4-(4-PYRIDYL)THIAZOLE;4-PYRIDIN-4-YL-1,3-THIAZOL-2-AMINE;4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE;4-(4-PYRIDINYL)-1,3-THIAZOL-2-YLAMINE;IFLAB-BB F0537-0969;BUTTPARK 37\12-54;2-Amino-4-pyridin-4-yl-1,3-thiazole;4-(4-PYRIDINYL)-2-THIAZOLAMINE
• CAS NO: 30235-28-0
• Molecular Formula: C₈H₇N₃S
• Molecular Weight: 177.23
• Product Categories: Amines;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 30235-28-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 270-272 °C
• Boiling Point: 378.9 °C at 760 mmHg
• Flash Point: 183 °C
• Appearance: /
• Density: 1.333 g/cm³
• Refractive Index: 1.67
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.89±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE(30235-28-0)
• EPA Substance Registry System: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE(30235-28-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 30235-28-0(Hazardous Substances Data)

Usage

Uses

4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE is a synthetic intermediate useful for pharmaceutical synthesis.

InChI:InChI=1/C8H7N3S/c9-8-11-5-7(12-8)6-1-3-10-4-2-6/h1-5H,(H2,9,11)

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 17356-08-0 thiourea 
• 6221-13-2 4-(bromoacetyl)pyridine 
• 1701-69-5 1-(4-pyridyl)-1-propanone 
• 5349-17-7 4-bromoacetylpyridine hydrobromide 
• 53289-47-7 2-chloro-1-pyridin-4-yl-ethanone 

Downstream Products

• 1187669-22-2 N-(3-methylbenzyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine 
• 393839-09-3 4-methoxy-N-[4-(4-pyridinyl)-1,3-thiazol-2-yl]benzamide 
• 476625-88-4 N-[4-(4-pyridinyl)-1,3-thiazol-2-yl]benzamide 
• 476631-30-8 3-methyl-N-[4-(4-pyridinyl)-1,3-thiazol-2-yl]benzamide 
• 692891-81-9 2-(3-(3-(N-Boc-piperidin-4-yl)-propoxy)-phenyl)-N-(4-pyridin-4-yl-thiazol-2-yl)-acetamide 
• 692885-22-6 C₁₇H₁₆N₄O₃S₂ 
• 692872-64-3 C₁₆H₁₄N₄OS 
• 692872-55-2 C₁₆H₁₃N₃O₂S 
• 692870-92-1 2-(3-hydroxyphenyl)-N-(4-pyridin-4-yl-thiazol-2-yl)-acetamide 
• 692872-59-6 C₁₆H₁₃N₃O₂S 
• 692869-38-8 C₁₇H₁₅N₃O₂S 
• 692870-97-6 C₁₇H₁₅N₃O₂S 
• 692869-52-6 C₁₆H₁₂FN₃OS 
• 692886-27-4 C₁₆H₁₂FN₃OS 

Relevant articles and documents

4-(Pyridin-4-yl)thiazol-2-amine as an efficient non-toxic inhibitor for mild steel in hydrochloric acid solutions

A novel eco-friendly corrosion inhibitor, namely, 4-(pyridin-4-yl)thiazol-2-amine (PTA), was synthesized and evaluated as a corrosion inhibitor for mild steel in 1 M HCl solution. Its inhibition effect against mild steel corrosion was investigated via weight loss methods, electrochemical measurements, and surface analyses. The experimental results showed that PTA is an effective corrosion inhibitor for mild steel in an acid medium, and the maximum inhibition efficiency reached 96.06% at 0.2 mM concentration. Polarization studies showed that PTA acted as a mixed inhibitor. The sorption behavior on the steel surface complies with the Langmuir adsorption isotherm, exhibiting both physisorption and chemisorption. The constitution and characteristic of the protective layer on the steel surface were verified using scanning electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDX) and UV-Vis spectroscopy. Quantum chemistry calculations were used to study the relationship between the inhibition efficiency and molecular structure of the inhibitor.

Design, synthesis, and biological evaluation of urea-based ROCK2 inhibitors

A series of urea-based ROCK2 inhibitors were design and synthesized. The inhibitory activity on ROCK2 was screened by enzyme-linked immunosorbent assay (ELISA). The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity. The most potent compound 10p showed ROCK2 inhibitory activity with the IC50?value of 0.03?μM. A preliminary structure-activity relationship was then summarized. The molecular docking studies showed that further optimization needs to conduct to obtain more potent ROCK inhibitors.

Novel tri-substituted thiazoles bearing piperazine ring: Synthesis and evaluation of their anticancer activity

Background: Cancer cells are described as an unregulated growth and spread of abnormal cells. Recently, cancer has become the most important major reason for deaths in the world. Methods: For anticancer activity, we have used the MTT method and determine