302584-95-8Relevant articles and documents
Synthesis and characterization of DNA containing O6-carboxymethylguanine
Xu, Yao-Zhong
, p. 6075 - 6081 (2007/10/03)
O6-Carboxymethylguanine was formed in DNA treated with N-nitrosoglycocholic acid and believed to be implicated in human gastrointestinal and colorectal tumour. An efficient method is presented here for synthesis of oligodeoxynucleotides containing O6-carboxy-methylguanine at pre-determined positions. The synthetic protocol also allows for production of oligomers containing O6-aminocarbonyl-methylguanine. These guanine-modified oligomers have been fully characterized and could provide a useful tool for biological studies of these modified bases. (C) 2000 Elsevier Science Ltd.