302839-21-0Relevant articles and documents
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis
Revesz, Laszlo,Blum, Ernst,Di Padova, Franco E.,Buhl, Thomas,Feifel, Roland,Gram, Hermann,Hiestand, Peter,Manning, Ute,Rucklin, Gerard
, p. 3595 - 3599 (2007/10/03)
A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38α inhibitors and in vivo in several models of rheumatoid arthritis. Four structures - 32, 37,