30293-82-4

Basic information

• Product Name: (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER
• Synonyms: (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER;METHYL (S)-(-)-2-ISOCYANATOPROPIONATE;Propanoic acid, 2-isocyanato-, methyl ester, (2S)- (9CI);Methyl (2S)-2-isocyanatopropanoate;(2S)-2-isocyanatopropanoic acid methyl ester;(2S)-2-isocyanatopropionic acid methyl ester;Methyl (S)-(-)-2-Isocyanatopropionate
• CAS NO: 30293-82-4
• Molecular Formula: C₅H₇NO₃
• Molecular Weight: 129.11
• Product Categories: GLYCINESCAFFOLD;Chiral Building Blocks;Isocyanates (Chiral);Synthetic Organic Chemistry
• Mol File: 30293-82-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 61 °C / 15mmHg
• Flash Point: 44°C
• Appearance: /
• Density: 1,12 g/cm3
• Vapor Pressure: 5.5mmHg at 25°C
• Refractive Index: -22.5 ° (C=neat)
• CAS DataBase Reference: (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER(30293-82-4)
• EPA Substance Registry System: (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER(30293-82-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: UN 2206 6.1/PG III
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 30293-82-4(Hazardous Substances Data)

Usage

General Description

(S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER is a chemical compound with the molecular formula C5H7NO3. It is a methyl ester of (S)-(-)-2-isocyanatopropanoic acid, which is an isocyanate compound. This chemical is commonly used in the synthesis of various organic compounds, and it is a versatile reagent in organic chemistry. It can also be used in the production of pharmaceuticals and agrochemicals. Additionally, (S)-(-)-2-ISOCYANATOPROPIONIC ACID METHYL ESTER has potential industrial applications, particularly in the development of new materials and polymers. Its properties and reactivity make it an important intermediate for the preparation of a wide range of products.

InChI:InChI=1/C5H7NO3/c1-4(6-3-7)5(8)9-2/h4H,1-2H3/t4-/m0/s1

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 13515-97-4 methyl 2-aminopropanoate monohydrochloride 
• 59943-97-4 N-Carbethoxy-2-aminopropionsaeuremethylester 
• 115294-42-3 N-phenoxycarbonyl-alanine methyl ester 
• 75-44-5 phosgene 
• 503-38-8 trichloromethyl chloroformate 
• 32221-83-3 (S)-N-formylalanine methyl ester 
• 67-56-1 methanol 
• 2185-12-8 α-Carboimidopropionylchlorid 

Downstream Products

• 112382-94-2 N-<(1S)-(1-methoxycarbonylethyl)carbamoyl>-L-valylglycyl-α-azanorvaline benzyl ester 
• 112382-93-1 N-<(1S)-(1-methoxycarbonylethyl)carbamoyl>-L-valyl-L-alanyl-α-azanorvaline benzyl ester 
• 112383-01-4 N-<(1S)-(1-methoxycarbonylethyl)carbamoyl>glycyl-L-valylglycyl-α-azanorvaline benzyl ester 
• 112382-97-5 N-<1(S)-(1-methoxycarbonylethyl)carbamoyl>-L-prolyl-α-azanorvaline benzyl ester 
• 112382-92-0 N-<(1S)-(1-methoxycarbonylethyl)carbamoyl>-L-valyl-L-prolyl-α-azanorvaline benzyl ester 
• 1432125-11-5 methyl 4-{2-[4-({[2-({3-[(4S)-4,7-dimethyl-3,6-dioxo-10-(pentan-3-yl)-2-oxa-5,7,10-triazaundecan-11-yl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoate 
• 1346608-12-5 ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-[({[1-methyl-2-(methyloxy)-2-oxoethyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate 
• 64991-79-3 2-Formylamino-2-methyl-3-(4-methylsulfanylcarbonimidoyl-phenyl)-propionic acid methyl ester 

Relevant articles and documents

ISOCYANATE PRODUCTION METHOD

An isocyanate production method according to the present invention is a method in which an isocyanate is produced by subjecting a carbamate to thermal decomposition, and includes: a step of preparing a mixture liquid containing the carbamate, an inactive solvent and a polyisocyanate compound; a step of conducting a thermal decomposition reaction of the carbamate by continuously introducing the mixture liquid into a thermal decomposition reactor; a step of collecting a low-boiling decomposition product by continuously extracting the low-boiling decomposition product in a gaseous state from the reactor, the low-boiling decomposition product having a boiling point lower than the polyisocyanate compound; and a step of collecting a high-boiling component by continuously extracting, from the reactor, a liquid phase component which is not collected in a gaseous state at the step of collecting the low-boiling decomposition product.

PRODUCTION METHOD OF ISOCYANATE

PROBLEM TO BE SOLVED: To provide a production method of isocyanate for producing isocyanate continuously by suppressing a side reaction. SOLUTION: A production method of isocyanate is a method for producing isocyanate by pyrolysis of carbamate. The method includes a pyrolysis process for performing a pyrolysis reaction of carbamate by introducing continuously a mixed liquid containing carbamate and a compound (A) having a specific structure into a pyrolysis reactor, a low-boiling point decomposition product recovery process for extracting, continuously from the pyrolysis reactor in a gas phase, a low-boiling point decomposition product having a lower normal boiling point than the compound (A), and a high-boiling point component recovery process for extracting, continuously from the pyrolysis reactor as a high-boiling point component, a liquid phase component not recovered in the gas phase in the low-boiling point decomposition product recovery process. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO-[5,1-D][1,2,3,5-TETRAZINE-8-CARBOXYLIC ACID AMIDES AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.