302939-86-2Relevant articles and documents
Structure-based design and profiling of novel 17β-HSD14 inhibitors
Braun, Florian,Bertoletti, Nicole,M?ller, Gabriele,Adamski, Jerzy,Frotscher, Martin,Guragossian, Nathalie,Madeira Gírio, Patrícia Alexandra,Le Borgne, Marc,Ettouati, Laurent,Falson, Pierre,Müller, Sebastian,Vollmer, Günther,Heine, Andreas,Klebe, Gerhard,Marchais-Oberwinkler, Sandrine
supporting information, p. 61 - 76 (2018/06/01)
The human enzyme 17β-hydroxysteroid dehydrogenase 14 (17β-HSD14) oxidizes the hydroxyl group at position 17 of estradiol and 5-androstenediol using NAD+ as cofactor. However, the physiological role of the enzyme remains unclear. We recently des
A highly practical and convenient halogenation of fused heterocyclic N-oxides
Wang, Dong,Wang, Yuxi,Zhao, Junjie,Li, Linna,Miao, Longfei,Wang, Dong,Sun, Hua,Yu, Peng
, p. 5762 - 5768 (2016/08/30)
A novel, simple and practical method for the regioselective halogenation of fused heterocyclic N-oxides has been developed. It employs Vilsmeier reagent, generated in situ by POX3and DMF, as both the activating agent and the nucleophilic halide source. The method is amenable across a broad range of substrates, including quinolines, isoquinolines and the diazine N-oxides, possessing a variety of substitution patterns. Furthermore, all of the reagents associated are cheap and easy to obtain. The potential extension of this method to a one-pot oxidation/halogenation sequence that obviates the need for isolation of the N-oxide intermediates is also presented.
Quinoline carboxamide-type ABCG2 modulators: Indole and quinoline moieties as anilide replacements
Bauer, Stefanie,Ochoa-Puentes, Cristian,Sun, Qiu,Bause, Manuel,Bernhardt, Günther,K?nig, Burkhard,Buschauer, Armin
supporting information, p. 1773 - 1778 (2014/01/06)
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