303-31-1

Basic information

• Product Name: 2-(2,6-dioxopiperidin-4-yl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-4-piperidinyl)-
• CAS NO: 303-31-1
• Molecular Formula: C₁₃H₁₀N₂O₄
• Molecular Weight: 258.2295
• Mol File: 303-31-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 215-270 °C
• Boiling Point: 509.7°C at 760 mmHg
• Flash Point: 262.1°C
• Density: 1.503g/cm³
• Vapor Pressure: 1.65E-10mmHg at 25°C
• Refractive Index: 1.646
• PKA: 10.86±0.40(Predicted)
• CAS DataBase Reference: 2-(2,6-dioxopiperidin-4-yl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-dioxopiperidin-4-yl)-1H-isoindole-1,3(2H)-dione(303-31-1)
• EPA Substance Registry System: 2-(2,6-dioxopiperidin-4-yl)-1H-isoindole-1,3(2H)-dione(303-31-1)

Safety Data

• Hazardous Substances Data: 303-31-1(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 

Relevant articles and documents

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TUNABLE ENDOGENOUS PROTEIN DEGRADATION WITH HETEROBIFUNCTIONAL COMPOUNDS

The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.