3038-47-9 Usage
Description
2-(TRIFLUOROMETHYL)PHENYLACETONITRILE, also known as 2-(Trifluoromethyl)-benzeneacetonitrile, is an off-white low melting crystalline solid. It is a chemical compound with the molecular formula C8H4F3N and is characterized by the presence of a trifluoromethyl group attached to a phenyl ring, which is connected to an acetonitrile group.
Uses
Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)PHENYLACETONITRILE is used as a key intermediate in the synthesis of non-peptide CCR1 receptor antagonists. These antagonists are important for the development of drugs targeting various inflammatory and autoimmune diseases, as they help modulate the immune response by blocking the action of certain receptors.
2-(TRIFLUOROMETHYL)PHENYLACETONITRILE is also used as a starting material in the synthesis of cyclopentimidazopyridinone and related compounds, which act as interleukin-6 inhibitors. These inhibitors have potential applications in the treatment of various inflammatory and autoimmune disorders, as well as certain types of cancer.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE is used in the facile synthesis of 1,2,3,4-tetrasubstituted naphthalenes. This is achieved through a condensation reaction with aromatic acetonitriles under basic conditions. The resulting tetrasubstituted naphthalenes have potential applications in various chemical and pharmaceutical industries due to their unique structural properties and potential for further functionalization.
Check Digit Verification of cas no
The CAS Registry Mumber 3038-47-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,3 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3038-47:
(6*3)+(5*0)+(4*3)+(3*8)+(2*4)+(1*7)=69
69 % 10 = 9
So 3038-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3N/c10-9(11,12)8-4-2-1-3-7(8)5-6-13/h1-4H,5H2
3038-47-9Relevant articles and documents
17a-HYDROXYLASE/C17,20-LYASE INHIBITORS
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Paragraph 0465, (2014/03/21)
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
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, (2008/06/13)
Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.
(Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines
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, (2008/06/13)
This disclosure describes substituted 1,2,4-triazolo[1,5-a]pyrimidines and substituted 1,2,4-triazolo[4,3-a]pyrimidines which possess anxiolytic activity.