30387-39-4

Basic information

• Product Name: COLISTIMETHATESODIUM
• Synonyms: Colistin A,1-[L-2-(6-methyloctanamido)-4-[(sulfomethyl)amino]butyricacid]-3-[L-2-amino-4-[(sulfomethyl)amino]butyricacid]-5-[L-2-amino-4-[(sulfomethyl)amino]butyricacid]-9-[L-2-amino-4-[(sulfomethyl)amino]butyric acid]- (8CI); Polymyxin E1,1-[N2-(6-methyl-1-oxooctyl)-N4-(sulfomethyl)-L-2,4-diaminobutanoicacid]-3-[N4-(sulfomethyl)-L-2,4-diaminobutanoicacid]-5-[N4-(sulfomethyl)-L-2,4-diaminobutanoic acid]-9-[N4-(sulfomethyl)-L-2,4-diaminobutanoicacid]-; 1,4,7,10,13,16,19-Heptaazacyclotricosane, cyclic peptide deriv.;Colistin-1,3,5,9-tetramethanesulfonic A acid
• CAS NO: 30387-39-4
• Molecular Formula: C57H108N16O25S4
• Molecular Weight: 1545.81962
• EINECS: 232-516-9
• Mol File: 30387-39-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: -1.00±0.50(Predicted)
• CAS DataBase Reference: COLISTIMETHATESODIUM(CAS DataBase Reference)
• NIST Chemistry Reference: COLISTIMETHATESODIUM(30387-39-4)
• EPA Substance Registry System: COLISTIMETHATESODIUM(30387-39-4)

Safety Data

• Hazardous Substances Data: 30387-39-4(Hazardous Substances Data)

Usage

General Description

Colistimethate Sodium, also known as Colistin, is a synthetic antibiotic medication known for its effectiveness against most forms of the bacteria Pseudomonas aeruginosa. It's often used as a last-resort treatment against multi-drug resistant strains. It works by disrupting the bacteria's cell membrane, leading to its death. This chemical is found to have a significant neurotoxic and nephroxic side effects. Additionally, this antibiotic can provoke serious allergy responses in some individuals. Despite its potential side effects, Colistimethate Sodium is still widely used in both human and veterinary medicine across the globe due to its potent anti-bacterial properties.

InChI:InChI=1/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5