304008-29-5 Usage
Description
N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide is a complex organic compound with a unique chemical structure. It is characterized by its trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide backbone, which contributes to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide is used as a neuropeptide Y Y5 receptor antagonist for its potential anxiolyticand antidepressant-like effects in mammalian models. This application is based on its ability to modulate the neuropeptide Y system, which is involved in the regulation of mood and anxiety.
Used in Research and Development:
In addition to its potential therapeutic applications, N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide may also be used in research and development for the study of neuropeptide Y receptors and their role in mood disorders. This can contribute to the development of new drugs and therapies for the treatment of anxiety and depression.
Check Digit Verification of cas no
The CAS Registry Mumber 304008-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,4,0,0 and 8 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 304008-29:
(8*3)+(7*0)+(6*4)+(5*0)+(4*0)+(3*8)+(2*2)+(1*9)=85
85 % 10 = 5
So 304008-29-5 is a valid CAS Registry Number.
304008-29-5Relevant articles and documents
Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder
Packiarajan, Mathivanan,Marzabadi, Mohammad R.,Desai, Mahesh,Lu, Yalei,Noble, Stewart A.,Wong, Wai C.,Jubian, Vrej,Chandrasena, Gamini,Wolinsky, Toni D.,Zhong, Hualing,Walker, Mary W.,Wiborg, Ove.,Andersen, Kim
, p. 5436 - 5441 (2011/10/12)
The structure-activity relationship of a series of tricyclic-sulfonamide compounds 11-32 culminating in the discovery of N-[trans-4-(4,5-dihydro-3,6- dithia-1-aza-benzo[e]azulen-2-ylamino)-cyclohexylmethyl]-methanesulfonamide (15, Lu AA33810) is reported. Compound 15 was identified as a selective and high affinity NPY5 antagonist with good oral bioavailability in mice (42%) and rats (92%). Dose dependent inhibition of feeding was observed after i.c.v. injection of the selective NPY5 agonist ([cPP1-7,NPY19-23,Ala 31,Aib32,Gln34]-hPP). In addition, ip administration of Lu AA33810 (10 mg/kg) produced antidepressant-like effects in a rat model of chronic mild stress.
