3041-40-5Relevant articles and documents
Industrial R&D on catalytic C-C and C-N coupling reactions: A personal account on goals, approaches and results
Blaser, Hans-Ulrich,Indolese, Adriano,Naud, Frederic,Nettekoven, Ulrike,Schnyder, Anita
, p. 1583 - 1598 (2004)
R&D issues for the application of Pd- and Ni-catalyzed C-C and C-N coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of C-C and C-N coupling for preparative applicatio
Single enantiomer, chiral donor-acceptor metal complexes from bisoxazoline pseudoracemates
Atkins, Jeffery M.,Moteki, Shin A.,DiMagno, Stephen G.,Takacs, James M.
, p. 2759 - 2762 (2006)
Single enantiomer, chiral donor-acceptor metal complexes were synthesized via the self-discriminating zinc(II) complexation of a pseudoracemic mixture of donor/acceptor-substituted bisoxazoline derivatives.
Structure-Activity Relationships of Pyrazolo[1,5- a]pyrimidin-7(4 H)-ones as Antitubercular Agents
Oh, Sangmi,Libardo, M. Daben J.,Azeeza, Shaik,Pauly, Gary T.,Roma, Jose Santinni O.,Sajid, Andaleeb,Tateishi, Yoshitaka,Duncombe, Caroline,Goodwin, Michael,Ioerger, Thomas R.,Wyatt, Paul G.,Ray, Peter C.,Gray, David W.,Boshoff, Helena I. M.,Barry, Clifton E.
, p. 479 - 492 (2021/01/26)
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of actio
A one-pot electrophilic cyanation–functionalization strategy for the synthesis of disubstituted malononitriles
Mills, L. Reginald,Rousseaux, Sophie A.L.
, p. 4298 - 4306 (2019/05/22)
Malononitriles are valuable synthetic intermediates for many applications, including the synthesis of herbicides and other biologically active molecules, and the synthesis of chiral ligands for asymmetric catalysis. This article describes the development of a procedure for the conversion of primary nitriles to malononitriles using dimethylmalononitrile, a commercial, non-toxic, carbon-bound source of electrophilic cyanide. This procedure avoids the use of toxic cyanide or malononitrile as a starting material. This protocol is further applied to the dicyanation of benzyl Grignard reagents, generated from benzyl bromides, yielding fully functionalized malononitriles from a nitrile-free precursor.