30433-93-3

Basic information

• Product Name: 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE
• Synonyms: AKOS ISYA01277;OTAVA-BB 1038642;1-(2-thienyl)propan-2-amine(SALTDATA: FREE);ASINEX-REAG BAS 10145056;1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE;RARECHEM AN KC 0145;TIMTEC-BB SBB010287;1-(2-THIENYL)PROPAN-2-AMINE
• CAS NO: 30433-93-3
• Molecular Formula: C7H11NS
• Molecular Weight: 141.23
• Mol File: 30433-93-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 210.8°C at 760 mmHg
• Flash Point: 81.3°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.188mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE(30433-93-3)
• EPA Substance Registry System: 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE(30433-93-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 30433-93-3(Hazardous Substances Data)

Usage

General Description

1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE, also known as 2-(2-Aminobenzyl)thiophene, is a chemical compound with the molecular formula C11H13NS. It is a yellow to brown liquid with a strong odor, and is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It is classified as an amine, with a thiophene ring and a methyl group attached to the amino group. 1-METHYL-2-THIOPHEN-2-YL-ETHYLAMINE has a variety of industrial and research applications, and its reactivity and unique structural properties make it a valuable tool in organic chemistry and drug development.

InChI:InChI=1/C7H11NS/c1-6(8)5-7-3-2-4-9-7/h2-4,6H,5,8H2,1H3

Upstream product

• 15022-18-1 1-(thiophen-2-yl)propan-2-one 
• 37629-59-7 (E)-2-(2-nitroprop-1-en-1-yl)thiophene 
• 6937-35-5 2-(2-nitroprop-1-enyl)thiophene 
• 98-03-3 thiophene-2-carbaldehyde 
• 23229-68-7 2-(prop-1-en-1-yl)thiophene 
• 20849-87-0 2-allylthiophene 
• 7664-41-7 ammonia 

Relevant articles and documents

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

Guanidine-containing compound as well as preparation method and application thereof

The invention discloses a cyanoguanidine-containing compound as well as a preparation method and application thereof. The invention also discloses a composition containing the cyanoguanidine-structured compound (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The invention also discloses application thereof in preparation of analgesic drugs. The compounds of the invention are useful in the treatment of various pain.

CARBOXYLIC ACID AMIDES AS FACTOR XA INHIBITORS

The present invention relates to new substituted carboxylic acid amides of general formula (I), wherein D, B, R3, R4 and R5 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.