30457-88-6Relevant articles and documents
Rh(III)-Catalyzed Csp2?Csp3 Bond Cleavage/Carbonylethylation of α-Indolyl Alcohols
Liu, Zhipeng,Hu, Xinwei,Yang, Can,Xie, Haisheng,Jiang, Huanfeng,Zeng, Wei
, p. 1672 - 1684 (2021)
A Rh(III)-catalyzed Csp2?Csp3 bond cleavage/carbonylethylation of α-indolyl alcohols with allylic alcohols has been reported. This transformation involved a cascade C?C bond cleavage/C?C bond formation, and provides a novel approach to assemble 2-carbonylethylindole skeletons. (Figure presented.).
Rhodium-Catalyzed Regio- And Enantioselective Allylic Amination of Racemic 1,2-Disubstituted Allylic Phosphates
Li, Changkun,Shu, Mouhai,Sun, Minghe,Xu, Wen-Bin
supporting information, p. 8255 - 8260 (2021/06/27)
Alkynylphosphines are rarely used as ligands in asymmetric metal catalysis. We synthesized a series of chiral bis(oxazoline)alkynylphosphine ligands and used them in Rh-catalyzed highly regio- and enantioselective allylic amination reactions of 1,2-disubstituted allylic phosphates. Chiral 1,2-disubstituted allylic amines were synthesized in up to 95% yield with >20:1 branched/linear (b/l) ratio and 99% ee from racemic 1,2-disubstituted allylic precursors. The sterically smaller linear alkynyl group on the P atom in the bis(oxazoline)alkynylphosphine ligands was the key to fit the new requirements of the introduction of bulky 2-R′ groups.
Enantioselective hydroesterificative cyclization of 1,6-enynes to chiral γ-lactams bearing a quaternary carbon stereocenter
Dong, Kaiwu,Li, Huimin,Ren, Xinyi,Shen, Chaoren,Tang, Lin,Wang, Peng
supporting information, p. 3561 - 3566 (2021/05/29)
A palladium-catalyzed asymmetric hydroesterification-cyclization of 1,6-enynes with CO and alcohol was developed to efficiently prepare a variety of enantioenriched γ-lactams bearing a chiral quaternary carbon center and a carboxylic ester group. The approach featured good to high chemo-, region-, and enantioselectivities, high atom economy, and mild reaction conditions as well as broad substrate scope. The correlation between the multiple selectivities of such process and the N-substitutes of the amide linker in the 1,6-enyne substrate has been depicted by the crystallographic evidence and control experiments.