30458-47-0Relevant articles and documents
Eco-friendly highly efficient solvent free synthesis of benzimidazole derivatives over sulfonic acid functionalized graphene oxide in ambient condition
Swami, Mantosh B.,Jadhav, Arvind H.,Mathpati, Sushil R.,Ghuge, Hanmant G.,Patil, Sudhakar G.
, p. 2033 - 2053 (2017/03/22)
Abstract: Sulfonated graphene oxide (GO-HSO3) heterogeneous catalyst was prepared at molecular level and characterized by using various modern analytic and spectroscopic methods. Using prepared heterogeneous catalyst GO-HSO3, benzimidazole synthesis was carried out by means of reacting diamine and aldehyde at room temperature in solvent free condition. The catalyst GO-HSO3 showed tremendous catalytic activity in selective synthesis of benzimidazole, as a result 100?% conversion of reactants and up to 89.0?% yield of respective benzimidazole was achieved using 0.1?mg of catalyst in very short reaction duration. The GO-HSO3 catalyst was separated from the reaction mixture by simple filtration process at the end of reaction and reused for six successive cycles without noteworthy loss of catalytic activity and selectivity. Key advantageous of this protocol is high yield, low cost, and easy work-up procedure as well as short reaction time and solvent free condition. The present method is found eco-friendly, highly efficient, solvent free, high yielding, and clean method for the synthesis benzimidazole derivatives at room temperature. Graphical Abstract: [Figure not available: see fulltext.]
Ligand-Free Pd/C-Catalyzed One-Pot, Three-Component Synthesis of Aryl-Substituted Benzimidazoles by Hydrogen-Transfer and Suzuki Reactions in Water
Xu, Chen,Xiao, Zhi-Qiang,Li, Hong-Mei,Han, Xin,Wang, Zhi-Qiang,Fu, Wei-Jun,Ji, Bao-Ming,Hao, Xin-Qi,Song, Mao-Ping
supporting information, p. 7427 - 7432 (2016/01/25)
An efficient protocol for the ligand-free and heterogeneous Pd/C-catalyzed one-pot, three-component synthesis of aryl-substituted benzimidazoles from benzyl alcohols by using water as the solvent was developed. The reaction involves hydrogen-transfer and Suzuki reactions. This method is quite convenient and environmentally friendly.
Studies on analgesic and anti-inflammatory activities of 1- dialkylaminomethyl-2-(p-substituted phenyl)-5-substituted benzimidazole derivatives
Ersan, Seyhan,Nacak, Sultan,Noyanalpan, Ningur,Yesilada, Erdem
, p. 834 - 836 (2007/10/03)
In this study the analgesic and anti-inflammatory activity of 1,2,5- trisubstituted benzimidazole derivatives have been examined. Analgesic activities of these compounds were investigated by using the modified Koster test. Among the compounds synthesized especially compound 1g (1- diethylaminomethyl)-2-(p-chlorophenyl)-5-nitro benzimidazole hydrochloride) has shown higher activity than acetylsalicylic acid (ASA) and indometacin. Compound 1e (1-(diethylaminomethyl)-2-(p-methoxyphenyl)-5-nitro benzimidazole hydrochloride, 1f (1-(diethylaminomethyl)-2-(p-tolyl)-5-nitro henzimidazole hydrochloride and 1i (1-(pipenridinomethyl)-2-(p-methoxyphenyl)-5-nitro benzimidazole hydrochloride) proved as potent as the standard ASA. Therefore the compounds 1e, 1f, 1g and 1i were screened for their anti-inflammatory activities using the carrageenan-induced hind paw edema test. Except 1g all compounds were almost inactive against this model of inflammation compared to indometacin.
