30459-17-7

Basic information

• Product Name: 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
• Synonyms: N-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE;N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE;1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE;1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE;1-(4-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE;4-PIPERAZINOBENZOTRIFLUORIDE;trifluoromethylphenylpiperazine;1-(4-Trifluormethylphenyl)-piperazine
• CAS NO: 30459-17-7
• Molecular Formula: C₁₁H₁₃F₃N₂
• Molecular Weight: 230.23
• EINECS: 250-210-3
• Product Categories: Piperidines, Piperidones, Piperazines;pharmacetical;piperazines;Building Blocks;C11;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 30459-17-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 88-92 °C
• Boiling Point: 309.1 °C at 760 mmHg
• Flash Point: 140.7 °C
• Appearance: Colorless to light yellow/Crystals
• Density: 1.203
• Vapor Pressure: 0.000654mmHg at 25°C
• Solubility: soluble in Methanol
• PKA: 8.79±0.10(Predicted)
• BRN: 523408
• CAS DataBase Reference: 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE(30459-17-7)
• EPA Substance Registry System: 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE(30459-17-7)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-34
• Hazardous Substances Data: 30459-17-7(Hazardous Substances Data)

Usage

Description

1-(4-Trifluoromethylphenyl)piperazine is a chemical compound that belongs to the class of piperazine derivatives. It is characterized by its colorless to light yellow crystalline appearance and is primarily utilized as a valuable research chemical in various scientific and pharmaceutical applications.

Uses

Used in Pharmaceutical Research:
1-(4-Trifluoromethylphenyl)piperazine is used as a research chemical for the development of novel pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the synthesis of new drugs and therapeutic agents.
Used in Chemical Synthesis:
1-(4-Trifluoromethylphenyl)piperazine is used as a key intermediate in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical and chemical industries. Its versatility as a building block allows for the creation of a wide range of molecules with diverse functionalities.
Used in Analytical Chemistry:
1-(4-Trifluoromethylphenyl)piperazine can be employed as a reference compound or standard in analytical chemistry, particularly in the development and validation of new analytical methods and techniques. Its distinct properties make it suitable for use in various chromatographic, spectroscopic, and other analytical procedures.

InChI:InChI=1/C11H13F3N2/c12-11(13,14)9-1-3-10(4-2-9)16-7-5-15-6-8-16/h1-4,15H,5-8H2/p+1

Upstream product

• 455-13-0 4-Iodobenzotrifluoride 
• 455-14-1 4-trifluoromethylphenylamine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 110-85-0 piperazine 
• 98-56-6 4-chlorobenzotrifluoride 
• 98-16-8 3-trifluoromethylaniline 
• 111-42-2 2,2'-iminobis[ethanol] 

Downstream Products

• 331767-19-2 9-{4-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide 
• 1015685-46-7 rac-6-chloro-3-(3-chloro-benzyl)-3-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-1,3-dihydro-indol-2-one 
• 91703-16-1 5-[4-(4-trifluoromethylphenyl)-piperazin-1-yl]pyrrolidin-2-one 
• 220000-88-4 4-(4-trifluoromethyl-phenyl)-pyridine 
• 67259-63-6 4-(4-(trifluoromethyl)phenyl)piperidine 
• 1268865-74-2 methyl 3-(4-fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylate 
• 1268862-81-2 3-(4-fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid 
• 1268865-26-4 methyl 2-phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylate 
• 1268862-36-7 2-phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid 
• 1268865-11-7 methyl 2-phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)quinoxaline-6-carboxylate 
• 866785-04-8 {3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-sulfonyl]-phenyl}-acetic acid methyl ester 
• 866787-69-1 1-(3-bromomethyl-benzenesulfonyl)-4-(4-trifluoromethyl-phenyl)-piperazine 
• 144881-43-6 5-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine 

Relevant articles and documents

PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN

Pyrazolo[1,5-a]pyrimidin-7(4H)-ones of formula (I) inhibit intraflagellar transport and are useful as anticancer agents and as probes of the function of dynein-dependent systems.

Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase

The management of blood glucose levels and the avoidance of diabetic hyperglycemia are common objectives of many therapies in the treatment of diabetes. An aryl piperazine compound 3a (RTC1) has been described as a promoter of glucose uptake, in part through a cellular mechanism that involves inhibition of NADH:ubiquinone oxidoreductase. We report herein the synthesis of 41 derivatives of 3a (RTC1) and a systematic structure-activity-relationship study where a number of compounds were shown to effectively stimulate glucose uptake in vitro and inhibit NADH:ubiquinone oxidoreductase. The hit compound 3a (RTC1) remained the most efficacious with a 2.57 fold increase in glucose uptake compared to vehicle control and micromolar inhibition of NADH:ubiquinone oxidoreductase (IC50 = 27 μM). In vitro DMPK and in vivo PK studies are also described, where results suggest that 3a (RTC1) would not be expected to provoke adverse drug-drug interactions, yet be readily metabolised, avoid rapid excretion, with a short half-life, and have good tissue distribution. The overall results indicate that aryl piperazines, and 3a (RTC1) in particular, have potential as effective agents for the treatment of diabetes.

METHODS FOR FORMING ARYL CARBON-NITROGEN BONDS USING LIGHT AND PHOTOREACTORS USEFUL FOR CONDUCTING SUCH REACTIONS

The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide with an amine in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.