304694-40-4

Basic information

• Product Name: N,N-Diethyl-N'-(4'-triflu...
• Synonyms: N,N-Diethyl-N'-(4'-triflu...;N,N-Diethyl-N'-(4'-trifluoroMethylbiphenyl-4-ylMethyl)-ethane-1,2-diaMine;N-(2-(DiethylaMino)ethyl)-4-(4-trifluoroMethylphenyl)benzylaMine;1,2-EthanediaMine, N1,N1-diethyl-N2-[[4'-(trifluoroMethyl)[1,1'-biphenyl]-4-yl]Methyl]-
• CAS NO: 304694-40-4
• Molecular Formula: C₂₀H₂₅F₃N₂
• Molecular Weight: 350.4211096
• Mol File: 304694-40-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N-Diethyl-N'-(4'-triflu...(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diethyl-N'-(4'-triflu...(304694-40-4)
• EPA Substance Registry System: N,N-Diethyl-N'-(4'-triflu...(304694-40-4)

Safety Data

• Hazardous Substances Data: 304694-40-4(Hazardous Substances Data)

Usage

General Description

The chemical "N,N-Diethyl-N'-(4'-trifluoromethylphenyl)-phosphoric diamide" is a phosphoric diamide compound that is used as a pesticide. It is commonly known by its trade name "Fipronil" and is used to control a variety of pests, including fleas, ticks, and ants. Fipronil works by targeting the central nervous system of insects, leading to paralysis and death. It has a broad spectrum of activity and is considered to be a highly effective insecticide. However, there have been concerns about its potential toxicity to non-target organisms, including humans, and its negative impact on the environment. Therefore, its use is regulated in many countries.

Upstream product

• 87199-17-5 4-formylphenylboronic acid, 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 1417526-18-1 C₂₀H₂₃F₃N₂ 
• 100-36-7 N,N-diethylethylenediamine 
• 90035-34-0 4-(4-trifluoromethylphenyl)benzaldehyde 

Downstream Products

• 1389264-17-8 darapladib 
• 412960-98-6 N-(2-diethylaminoethyl)-2-[2-(2-(2,3-difluorophenyl)ethyl)-4-oxo-4,5,6,7-tetrahydro-cyclopentapyrimidin-1-yl]-N-(4'-trifluoromethyl-biphenyl-4-ylmethyl)acetamide 
• 356057-34-6 N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]thio}-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-{[4’-(trifluoromethyl)-4-biphenylyl]methyl}acetamide 

Relevant articles and documents

Oxazolidinone compound as well as preparation method, application and pharmaceutical composition thereof

The invention relates to an oxazolidinone compound used as an Lp-PLA2 covalent inhibitor and a pharmaceutical composition of the oxazolidinone compound, the structure of the oxazolidinone compound isshown as a general formula I, and R1, R2 and R3 are defined as the specification and claims. The compound shown in the general formula I or the stereoisomer or the pharmaceutically acceptable salt thereof can be used as the Lp-PLA2 covalent inhibitor to prevent and/or treat and/or improve diseases related to Lp-PLA2 enzyme activity. Meanwhile, the stereoisomer or the pharmaceutically acceptable salt of the compound shown in the general formula I can be used as an Lp-PLA2 specific molecular probe.

Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis

Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera

PROCESSES FOR THE PREPARATION OF DARAPLADIB AND ITS INTERMEDIATES

The present invention provides a process for the preparation of ethyl {2-[(4- fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetate of Formula 4, {2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta [d]pyri