30482-01-0Relevant articles and documents
An efficient water-mediated synthetic route for the alkylation of heteroarenes
Seyi?Tdanlio?lu, P?nar,Hanashalshahaby, Essam Hamied Ahmed,ünalero?lu, Canan
, p. 1598 - 1610 (2018)
An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.