30510-67-9

Basic information

• Product Name: 2-AMINO-N-CYCLOPROPYLBENZAMIDE
• Synonyms: benzamide, 2-amino-N-cyclopropyl-;2-amino-N-cyclopropylbenzamide(SALTDATA: FREE)
• CAS NO: 30510-67-9
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 30510-67-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 389.5 °C at 760 mmHg
• Flash Point: 189.4 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 2.84E-06mmHg at 25°C
• Refractive Index: 1.61
• PKA: 14.43±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-N-CYCLOPROPYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-CYCLOPROPYLBENZAMIDE(30510-67-9)
• EPA Substance Registry System: 2-AMINO-N-CYCLOPROPYLBENZAMIDE(30510-67-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30510-67-9(Hazardous Substances Data)

Usage

General Description

2-Amino-N-Cyclopropylbenzamide, also known as CAS No. 875458-26-5, belongs to the chemical class of 'organonitrogen compounds.' It is an organic compound that contains an amide functional group with a cyclopropane ring attached. With a molecular weight of approximately 189.224 g/mol, it is characterized by its molecular structure that includes an aromatic benzene ring combined to an amide group and cyclopropyl group. While there isn't significant information on its applications, such compounds are typically employed in pharmaceuticals or as chemical intermediates for synthesizing other complex molecules in labs or the chemical industry. Further studies may be needed to understand its biological activities, ecological toxicity, or health safety concerns, which are currently undocumented.

InChI:InChI=1/C10H12N2O/c11-9-4-2-1-3-8(9)10(13)12-7-5-6-7/h1-4,7H,5-6,11H2,(H,12,13)

Upstream product

• 88229-20-3 N-cyclopropyl-2-nitrobenzamide 
• 118-92-3 anthranilic acid 
• 765-30-0 Cyclopropylamine 
• 5344-90-1 2-Aminobenzyl alcohol 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1243325-00-9 2-{[(cyclopropyl)amino]methyl}aniline 
• 146381-56-8 3-cyclopropyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 1448791-12-5 2-(4-chloro-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)-N-cyclopropylbenzamide 
• 953048-70-9 N-cyclopropyl-2-((2,5-dichloropyrimidin-4-yl)amino)benzamide 
• 1341200-51-8 (2-(5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N-cyclopropylbenzamide 
• 554458-02-5 (2-cyclopropylcarbamoyl-phenyl)-carbamic acid methyl ester 

Relevant articles and documents

Simple and Efficient Amberlite 15-catalyzed Synthesis of Dihydroquinazolinones

Abstract: The Amberlite 15 catalyzed synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones was reported. The reaction conditions were optimized by screening in different solvents and catalysts. The substrate scope of the reaction was also studied, and

Design, synthesis, in vitro and in silico biological assays of new quinazolinone-2-thio-metronidazole derivatives

A new series of quinazolinone-2-thio-metronidazole derivatives 9a-o was designed, synthesized and assayed for their activities against metabolic enzymes human carbonic anhydrase I and II (hCAs I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase. The results indicated that all the synthesized compounds exhibited excellent inhibitory activities against mentioned enzymes as compared with standard inhibitors. Representatively, the most potent compound against CA enzymes, 4-fluorophenyl derivative 9i, was 4 and 7-times more potent than standard inhibitor acetazolamide against hCA I and II, respectively; 4-fluorobenzyl derivative 9m as the most potent compound against cholinesterase enzymes, was around 11 and 21-times more potent than standard inhibitor tacrine against AChE and BChE, respectively; the most active α-glucosidase inhibitor 9h with 4-methoxyphenyl moiety was 5-times more active that acarbose as standard inhibitor. Furthermore, in order to study interaction modes of the most potent compounds in the active site of their related enzymes, molecular modeling was performed. Druglikeness, ADME, and toxicity profile of the compounds 9i, 9m, and 9h were also predicted.

A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones

A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.