3055-94-5Relevant articles and documents
Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols
Yu, Zeqiong,Bo, Shaowei,Wang, Huiyuan,Li, Yu,Yang, Zhigang,Huang, Yongzhuo,Jiang, Zhong-Xing
, p. 3473 - 3479 (2017)
Polydisperse PEGs are ubiquitously used in pharmaceutical industry and biomedical research. However, the monodispersity in PEGs may play a role in the development of safe and effective PEGylated small molecular drugs. Here, to avoid the polydispersity in polidocanol, the active ingredient in a clinically used drug, a macrocyclic sulfate-based strategy for the efficient and scalable synthesis of monodisperse polidocanols, their sulfates, and their methylated derivatives, was developed. TLC and HPLC analysis indicated a complex mixture in regular polidocanol and high purities in monodisperse polidocanols and their derivatives. Assay on HUVEC, L929, and HePG2 cells showed that monodisperse polidocanols have much higher cytotoxicity and safety than that of regular polidocanol. It was found that the monodispersity of PEGs in polidocanols is crucial for achieving the optimal therapeutic results. Therefore, based on this case study, it would be beneficial to optimize PEGylated small molecular drugs with monodisperse PEGs in pharmaceutical research and development.
Drug carrier based on sulfonium lipidosome structure and preparation method and application of drug carrier
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Paragraph 0049; 0061-0063, (2019/08/14)
The invention relates to the technical field of medicine, in particular to a sulfonium compound shown as a general formula (A), and discloses a preparation method of the compound. The compound is poly-condensed with genes to form a nanometer compound with the particle size of 100-300 nm and Zeta potential of +20-+40. The gene loading capability of the sulfonium compound enables the sulfonium compound to have potential application in gene transfer.
Synthesis and surface properties of N,N-dimethyl-N-dodecyl polyoxyethylene amine-based surfactants: Amine oxide, betaine and sulfobetaine
Hou, Liya,Zhang, Huinian,Chen, Hui,Xia, Qibo,Huang, Dongyang,Meng, Li,Liu, Xuefeng
, p. 403 - 408 (2014/05/20)
Nonionic-zwitterionic hybrid surfactants, namely N,N-dimethyl-N-dodecyl polyoxyethylene (3) amine oxide, and the corresponding betaine and/or sulfobetaine, have been synthesized. Their molecule structures were characterized by means of electrospray ionization mass spectrometry and 1H nuclear magnetic resonance. Compared to the structurally related conventional amine oxide, betaine and sulfobetaine, the critical micelle concentrations of the three hybrid surfactants are one order of magnitude smaller than those of traditional ones. The polyoxyethylene segment between the hydrophilic head group and the hydrophobic tail makes the surface activities of the hybrid surfactants superior to their structure-related counterparts.