30563-87-2

Basic information

• Product Name: 2,4-Pyrimidinediamine, 6-chloro-5-[(3,4,5-trimethoxyphenyl)methyl]-
• CAS NO: 30563-87-2
• Molecular Formula: C14H17ClN4O3
• Molecular Weight: 324.767
• Mol File: 30563-87-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-Pyrimidinediamine, 6-chloro-5-[(3,4,5-trimethoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrimidinediamine, 6-chloro-5-[(3,4,5-trimethoxyphenyl)methyl]-(30563-87-2)
• EPA Substance Registry System: 2,4-Pyrimidinediamine, 6-chloro-5-[(3,4,5-trimethoxyphenyl)methyl]-(30563-87-2)

Safety Data

• Hazardous Substances Data: 30563-87-2(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 350986-48-0 (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid 
• 29958-02-9 2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester 
• 37389-83-6 2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-6-hydroxy-pyrimidine 
• 51323-79-6 2-amino-4,6-dichloro-5-(3,4,5-trimethoxybenzyl)pyrimidine 

Downstream Products

• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 

Relevant articles and documents

An efficient benzyltriethylammonium chloride catalysed preparation of electrophilic alkenes: a practical synthesis of trimethoprim

The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yeilds: the scope of this protocol is utilised for the synthesis of the antibacterial agent trimethoprim.

Process for the manufacture of pyrimidine derivatives

A process for the manufacture of 2,4-diamino-5-(substituted benzyl)pyrimidines from the corresponding 6-hydroxy-derivatives or the hydrochloride thereof by (a) chlorinating with phosphoryl chloride in presence of a considerable excess of hydrogen chloride and (b) hydrogenation of the thus easily in practically pure form and with high yields obtained 6-chloro derivatives.