30573-88-7

Basic information

• Product Name: 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER;Benzenepropanoic acid, 2-chloro-, ethyl ester;ethyl 3-(3-chlorophenyl)propanoate;Ethyl 3-(2-chlorophenyl)propanoate
• CAS NO: 30573-88-7
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.67272
• Mol File: 30573-88-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 278°C at 760 mmHg
• Flash Point: 129.1°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 0.00437mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(30573-88-7)
• EPA Substance Registry System: 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(30573-88-7)

Safety Data

• Hazardous Substances Data: 30573-88-7(Hazardous Substances Data)

Usage

Description

3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER is a chemical compound that belongs to the class of propionic acid derivatives. It is an ethyl ester of 3-(2-chloro-phenyl)-propionic acid, which is a nonsteroidal anti-inflammatory drug (NSAID). 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER possesses anti-inflammatory properties and is used in various applications due to its potential therapeutic effects.

Uses

Used in Pharmaceutical Industry:
3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER is used as a drug or intermediate in the synthesis of other drugs for its anti-inflammatory properties. It aids in the management and treatment of inflammation and pain, providing relief to patients suffering from various inflammatory conditions.
Used in Scientific Research:
3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER is used as a research reagent in scientific studies related to inflammation and pain. It helps researchers understand the underlying mechanisms of these conditions and develop new therapeutic strategies to combat them.
It is important to handle 3-(2-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER with caution, as it may pose health risks if not handled properly. Proper safety measures should be taken to minimize any potential hazards associated with its use.

InChI:InChI=1/C11H13ClO2/c1-2-14-11(13)8-7-9-5-3-4-6-10(9)12/h3-6H,2,7-8H2,1H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 3752-25-8 o-chlorocinnamic acid 
• 24393-51-9 ethyl 3-(2-chlorophenyl)acrylate 
• 24393-51-9 (E)-ethyl 2-chlorocinnamate 

Downstream Products

• 6282-87-7 3-(2-chlorophenyl)-propanol 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 63204-41-1 5-(2-chloro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 63204-21-7 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-chlorobenzyl)-4-pyrimidone dihydrochloride 
• 63204-42-2 5-(2-chlorobenzyl)-2-methylthio-4-pyrimidone 
• 15115-59-0 4-chloro-2,3-dihydro-1H-inden-1-one 
• 3199-71-1 4-chloro-2,3-dihydro-1H-inden-1-ol 
• 103391-83-9 N-(2-(2-chlorophenyl)propyl)aniline 
• 65424-65-9 5-(2-chloro-benzyl)-pyrimidine-2,4-diamine 
• 26452-97-1 1-cyanoindane 
• 90347-04-9 1-chloro-2-(3-chloro-propyl)-benzene 
• 92553-53-2 1-Phenylmercapto-3-(2-chlor-phenyl)-propan 
• 92553-38-3 <3-(2-Chlor-phenyl)-propyl>-phenyl-sulfon 
• 92549-12-7 Phenyl--sulfon 

Relevant articles and documents

Inhibition of uridine phosphorylase: Synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2- hydroxyethoxy)methyl]-5-benzyluracils

A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine and 5-fluorouracil and to ameliorate zidovudine- induced anemia in animal models. We prepared a series of 5-aryl-substituted analogues of 5-benzylacyclouridine (BAU), a good inhibitor of UrdPase (IC50 of 0.46 μM), to develop a compound with enhanced potency and improved pharmacokinetics. The first phase of structure-activity relationship studies on a series of 32 aryl-substituted 5-benzyluracils found several 5-(3- alkoxybenzyl) analogues of 5-benzyluracil with enhanced potency. The acyclovir side chain, the (2-hydroxyethoxy)methyl group, was substituted on the more potent aryl-substituted 5-benzyluracils. The two most potent compounds, 10y (3-propoxy) and 10dd (3-sec-butoxy), were inhibitors of UrdPase with IC50s of 0.047 and 0.027 μM, respectively. Six compounds were tested in vivo for effects on steady-state concentrations of circulating uridine in rats. Plasma uridine levels were elevated 3-9-fold by compound levels that ranged from 8 to 50 μM.

SYNTHESE TOTALE DE STEROIDES A CYCLE C AROMATIQUE

The ring-C aromatic analogue 4 of 4-androstene 3,17-dione and its 11 hydroxylated(methoxylated) derivatives 20a(b) were prepared by a practical synthetic route.The key steps of the sequence are achieved in superacid: the cyclisation of diarylethane 5a to phenanthrenone 17, and the hydroxylation by hydrogenperoxide of ketone 4 to phenol 20a.