305819-03-8

Basic information

• Product Name: C₄₀H₆₀O₅Si₂
• CAS NO: 305819-03-8
• Molecular Weight: 677.084
• Mol File: 305819-03-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₀H₆₀O₅Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₀H₆₀O₅Si₂(305819-03-8)
• EPA Substance Registry System: C₄₀H₆₀O₅Si₂(305819-03-8)

Safety Data

• Hazardous Substances Data: 305819-03-8(Hazardous Substances Data)

Upstream product

• 305819-02-7 1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-3-methylene-cyclobutane 
• 305819-15-2 3,3-bis(((tert-butyldimethylsilyl)oxy)methyl)cyclobutan-1-one 
• 305819-01-6 3,3-bis-hydroxymethyl-cyclobutanone 
• 115118-68-8 3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester 
• 130369-33-4 (1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 305819-16-3 [3,3-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclobutyl]-methanol 

Downstream Products

• 305819-04-9 C₄₂H₄₄O₉S₂ 
• 305819-06-1 3-(1,3-dithiacyclohex-2-yl)-1,1-di(p-tosyloxymethyl)cyclobutane 
• 305819-17-4 C₂₁H₂₆O₇S₂ 
• 305819-05-0 C₂₁H₂₄O₇S₂ 
• 305819-07-2 C₁₇H₂₂O₃S₃ 

Relevant articles and documents

Conformationally locked nucleosides. Synthesis of 3(R,S)-(adenin-9-y1)-1- and 3(R,S)-(cytosin-1-y1)-1-hydroxymethylbicyclo[2,1,1]hexanes

3,3-Di(isopropoxycarbonyl)-1,1-dimethoxycyclobutane (1) was converted, in multi-steps, to 3-(1,3-dithiacyclohex-2-yl)-1,1-di(p-tosyloxymethyl)cyclobutane (7), which was subjected to a butyllithium-mediated cyclization to give the bicyclo[2,1,1]hexane ring system 8. Further transformations afforded 1-(t-butyldimethylsilyloxymethyl)-3(R,S)-hydroxybicyclo[2,1,1]hexanes (11), which were condensed with 6-chloropurine and 4-acetylcytosine via Mitsunobu reactions to give, after further treatment, 3(R,S)-(adenin-9-yl)- and 3(R,S)-(cytosin-1-yl)-1-hydroxymethylbicyclo[2,1,1]hexanes (14 and 17), respectively. (C) 2000 Elsevier Science Ltd.