30594-15-1

Basic information

• Product Name: ethyl diethenylphosphinate
• Synonyms: Phosphinic acid, diethenyl-, ethyl ester
• CAS NO: 30594-15-1
• Molecular Formula: C₆H₁₁O₂P
• Molecular Weight: 146.1241
• Mol File: 30594-15-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 167.8°C at 760 mmHg
• Flash Point: 69.7°C
• Density: 0.985g/cm³
• Vapor Pressure: 2.21mmHg at 25°C
• Refractive Index: 1.425
• CAS DataBase Reference: ethyl diethenylphosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl diethenylphosphinate(30594-15-1)
• EPA Substance Registry System: ethyl diethenylphosphinate(30594-15-1)

Safety Data

• Hazardous Substances Data: 30594-15-1(Hazardous Substances Data)

Upstream product

• 1498-51-7 ethyl phosphodichloridite 
• 1826-67-1 vinyl magnesium bromide 
• 30594-09-3 Bis-(2-chlor-ethyl)-phosphinsaeure-ethylester 
• 64-17-5 ethanol 
• 34833-61-9 divinylphosphinic acid chloride 

Downstream Products

• 1042424-99-6 (S)-N-{3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 1042426-00-5 methanesulfonic acid (R)-3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl-2-oxo-oxazolin-5-yl]methyl ester 
• 1042425-96-6 [4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester 
• 1042426-02-7 (R)-5-azidomethyl-3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]-azaphosphinan-1-yl)-3-fluoro-phenyl]-oxazolidin-2-one 
• 1042425-98-8 (R)-3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl]-5-hydroxymethyl-oxazolidin-2-one 
• 1042425-94-4 4-ethoxy-1-(2-fluoro-4-nitro-phenyl)-[1,4]azaphosphinane 4-oxide 
• 1042425-95-5 4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl-amine 
• 1042425-92-2 1-benzyl-4-ethoxy-1,4lambda5-azaphosphinane 4-oxide 

Relevant articles and documents

Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa)

Selective and potent inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) have the potential to increase endogenous and therapeutic fibrinolysis and to behave like profibrinolytic agents without the risk of major hemorrhage, since they do not interfere either with platelet activation or with coagulation during blood hemostasis. Therefore, TAFIa inhibitors could be used in at-risk patients for the treatment, prevention, and secondary prevention of stroke, venous thrombosis, and pulmonary embolisms. In this paper, we describe the design, the structure-activity relationship (SAR), and the synthesis of novel, potent, and selective phosphinanes and azaphosphinanes as TAFIa inhibitors. Several highly active azaphosphinanes display attractive properties suitable for further in vivo efficacy studies in thrombosis models.

Insertion of Arynes into P-O Bonds: One-Step Simultaneous Construction of C-P and C-O Bonds

The insertion of arynes into P-O bonds for the preparation of o-hydroxy-substituted arylphosphine oxides, -phosphinates, and -phosphonates is described. This novel reaction leads to the simultaneous formation of C-P and C-O bonds in one step with good yie