30626-96-1 Usage
Description
7α-Hydroxypregnenolone is a neuroactive metabolite of pregnenolone, a steroid hormone naturally produced in the body. It plays a crucial role as a neuromodulator, enhancing locomotor activity and contributing to various physiological functions.
Uses
Used in Pharmaceutical Industry:
7α-Hydroxypregnenolone is used as a neuromodulator for its ability to increase locomotor activity. This application is particularly relevant in the development of treatments for conditions that affect motor function and cognitive abilities.
Used in Research and Development:
7α-Hydroxypregnenolone serves as an important compound in scientific research, particularly in the fields of neuroscience and endocrinology. It is used to study the effects of neurosteroids on the central nervous system and to develop new therapeutic strategies for neurological disorders.
Used in Drug Delivery Systems:
Similar to gallotannin, 7α-Hydroxypregnenolone could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. This application would involve the development of novel carriers and formulations to improve the delivery of the compound to target tissues and cells.
Discovery
7α-Hydroxylation of pregnenolone was found in the rat brain.Subsequently, 7α-hydroxypregnenolone formation was demonstrated in the brains of various vertebrates and in the pineal glands of birds.
Gene, mRNA, and precursor
The human P4507α gene (CYP7B1), located on chromosome 8 (8q21.3), consists of six exons.Human P4507αmRNA has 2395bp that encodes a protein of 506 aa residues.
Biological functions
Dopamine neurons are located in the medial brain region, specifically in the TA and posterior tuberal nucleus; they project to the rostral brain region including the striatum.7α-Hydroxypregnenolone increases the concentration of dopamine in the telencephalic region?including the striatum,which is known to be involved in the regulation of locomotor behavior in vertebrates. Thus, there is potential for the direct regulation of dopamine release by the action of 7α-hydroxypregnenolone synthesized in the TA. Acute stress increases the synthesis of 7α-hydroxypregnenolone through corticosterone action in newts.7α-Hydroxypregnenolone increases serotonin concentrations in the diencephalon including the DMH under stress.The pineal gland, an endocrine organ located close to the brain, is an important site of production of neurosteroids de novo from cholesterol in birds.7α-Hydroxypregnenolone is a major pineal neurosteroid that stimulates locomotor activity in juvenile chickens, connecting light-induced gene expression with locomotion.
Clinical implications
7α-Hydroxypregnenolone administration to memory impaired aged rats for 11 days enhanced spatial memory retention in the eight-arm radial-arm version of the water maze.
Check Digit Verification of cas no
The CAS Registry Mumber 30626-96-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,6,2 and 6 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 30626-96:
(7*3)+(6*0)+(5*6)+(4*2)+(3*6)+(2*9)+(1*6)=101
101 % 10 = 1
So 30626-96-1 is a valid CAS Registry Number.
30626-96-1Relevant articles and documents
Cholesterol transformations during heat treatment
Derewiaka,Molińska
, p. 233 - 240 (2015/01/09)
The aim of the study was to characterise products of cholesterol standard changes during thermal processing. Cholesterol was heated at 120 °C, 150 °C, 180 °C and 220 °C from 30 to 180 min. The highest losses of cholesterol content were found during thermal processing at 220 °C, whereas the highest content of cholesterol oxidation products was observed at temperature of 150 °C. The production of volatile compounds was stimulated by the increase of temperature. Treatment of cholesterol at higher temperatures i.e. 180 °C and 220 °C led to the formation of polymers and other products e.g. cholestadienes and fragmented cholesterol molecules. Further studies are required to identify the structure of cholesterol oligomers and to establish volatile compounds, which are markers of cholesterol transformations, mainly oxidation.
