306314-21-6

Basic information

• Product Name: (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester
• Synonyms: (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester
• CAS NO: 306314-21-6
• Molecular Weight: 723.711
• Mol File: 306314-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester(306314-21-6)
• EPA Substance Registry System: (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester(306314-21-6)

Safety Data

• Hazardous Substances Data: 306314-21-6(Hazardous Substances Data)

Upstream product

• 306314-19-2 (3S,4R)-4-[(S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionylamino]-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 
• 306314-18-1 (S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionic acid 
• 306314-17-0 (S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionic acid methyl ester 
• 306314-14-7 4-(N-carbobenzoxy)amino-3-hydroxy-5,5,5-trifluoropentanoic acid 
• 306314-15-8 (3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 
• 306314-16-9 (3S,4R)-4-Amino-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 
• 108-12-3 isopentanoyl chloride 
• 3918-94-3 Val-Val 
• 59452-57-2 N-isovaleryl-L-valyl-L-valine 
• 306314-20-5 (3S,4R)-4-[(S)-2-((3S,4R)-4-Amino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionylamino]-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 

Relevant articles and documents

Total synthesis of a Pepstatin analogue incorporating two trifluoromethyl hydroxymethylene isosteres

The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two α-Tfm-amino β-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity. (C) 2000 Elsevier Science Ltd.