3066-86-2 Usage
Description
5-Bromocytidine, a pyrimidine nucleoside, is a chemical compound derived from cytidine with a bromine atom attached at the 5th position. It possesses unique properties that make it a valuable component in various scientific and medical applications.
Uses
Used in Pharmaceutical Industry:
5-Bromocytidine is used as a key intermediate in the synthesis of substituted cytidine analogs. These analogs have potential applications in the development of new antiviral and anticancer drugs due to their ability to interfere with the replication and transcription processes of viruses and cancer cells.
Used in Antiviral Research:
5-Bromocytidine serves as a potent inhibitor of viral RNA-dependent RNA polymerases (RdRp). It has demonstrated its effectiveness in inhibiting the replication of the influenza virus in cell culture, making it a promising candidate for the development of antiviral therapies targeting a wide range of RNA viruses.
Used in Molecular Biology:
In molecular biology, 5-Bromocytidine can be utilized as a building block for the creation of modified nucleic acids, which can be employed in various research applications, such as studying gene expression, understanding protein-nucleic acid interactions, and developing novel gene editing tools.
Used in Diagnostics:
5-Bromocytidine can be used in the development of diagnostic tools and assays, particularly those involving the detection and quantification of specific viral or cellular RNA sequences. Its unique chemical properties allow for the design of highly specific and sensitive detection methods.
Used in Drug Development:
As a precursor in the synthesis of cytidine analogs, 5-Bromocytidine plays a crucial role in the development of new drugs targeting various diseases, including viral infections and cancer. Its ability to inhibit viral replication and interfere with cellular processes makes it a valuable starting point for the design and optimization of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 3066-86-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,6 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3066-86:
(6*3)+(5*0)+(4*6)+(3*6)+(2*8)+(1*6)=82
82 % 10 = 2
So 3066-86-2 is a valid CAS Registry Number.
3066-86-2Relevant articles and documents
A general approach to the synthesis of 5-S-functionalized pyrimidine nucleosides and their analogues
Kananovich, Dzmitry G.,Reino, Alli,Ilmarinen, Kaja,Roomusoks, Marko,Karelson, Mati,Lopp, Margus
, p. 5634 - 5644 (2014/07/22)
A general and efficient approach was developed for the introduction of S-functionality at the C-5 position of cytosine and uracil nucleosides and their analogues. The key step is a palladium-catalyzed C-S coupling of the corresponding 5-bromo nucleoside derivative and alkyl thiol. The butyl 3-mercaptopropionate coupling products were further converted to the corresponding disulphides, the stable precursors of 5-mercaptopyrimidine nucleosides. the Partner Organisations 2014.
Bromination at C-5 of pyrimidine and C-8 of purine nucleosides with 1,3-dibromo-5,5-dimethylhydantoin
Rayala, Ramanjaneyulu,Wnuk, Stanislaw F.
experimental part, p. 3333 - 3336 (2012/07/30)
Treatment of the protected and unprotected nucleosides with 1,3-dibromo-5,5-dimethylhydantoin in aprotic solvents such as CH 2Cl2, CH3CN, or DMF effected smooth bromination of uridine and cytidine derivatives at C-5 of pyrimidine rings as well as adenosine and guanosine derivatives at C-8 of purine rings. Addition of Lewis acids such as trimethylsilyl trifluoromethanesulfonate enhanced the efficiency of bromination.
CYTIDINE ANALOGS AND METHODS OF USE
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Page/Page column 21, (2010/02/08)
Cytidine analogs, their prodrugs and/or metabolites are employed as pharmaceutically active compounds for treatment of diseases responsive to such compounds. Particularly preferred diseases include viral diseases (e.g., HCV infection) and neoplasms.
