3067-10-5

Basic information

• Product Name: 5-Methoxy-7-hydroxycoumarin
• Synonyms: 5-Methoxy-7-hydroxycoumarin
• CAS NO: 3067-10-5
• Molecular Formula: C₁₀H₈O₄
• Molecular Weight: 192.16812
• Mol File: 3067-10-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 429.9°Cat760mmHg
• Flash Point: 179.6°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 5-Methoxy-7-hydroxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-7-hydroxycoumarin(3067-10-5)
• EPA Substance Registry System: 5-Methoxy-7-hydroxycoumarin(3067-10-5)

Safety Data

• Hazardous Substances Data: 3067-10-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8O4/c1-13-8-4-6(11)5-9-7(8)2-3-10(12)14-9/h2-5,11H,1H3

Upstream product

• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 
• 77-78-1 dimethyl sulfate 
• 2174-64-3 5-methoxyresorcinol 
• 623-47-2 propynoic acid ethyl ester 
• 4221-48-1 7-acetoxy-5-methoxy-chromen-2-one 
• 471-25-0 Propiolic acid 
• 101-38-2 2,6-dichloroquinone-4-chloroimide 
• 79326-04-8 5-Hydroxy-6-methoxycoumarin 
• 91136-78-6 7-hydroxy-5-methoxy-2-oxo-2H-chromene-3-carboxylic acid 
• 108-73-6 3,5-dihydroxyphenol 
• 3519-76-4 2,4-dihydroxy-6-methoxybenzaldehyde 
• 53277-19-3 2,4,6-triacetoxybenzaldehyde 
• 164329-24-2 2,4-diacetoxyl-6-hydroxybenzaldehyde 
• 487-70-7 2,4,6-trihydroxybenzaldehyde 

Downstream Products

• 484-20-8 bergapten 
• 2107-76-8 4-methyl-5,7-dihydroxycoumarin 
• 95-57-8 2-monochlorophenol 
• 84-99-1 xanthoxyletin 
• 31525-76-5 5-methoxyseselin 
• 30779-96-5 5-methoxy-7-O-(3,3-dimethylallyl)coumarin 

Relevant articles and documents

A catalyst-free one-pot construction of skeletons of 5-methoxyseselin and alloxanthoxyletin in water

In refluxing water and without an additional catalyst, electron-rich phenols could react with alkynoic acids or alkynoates to provide coumarin structures. The skeletons of two natural pyranocoumarins, 5-methoxyseselin and alloxanthoxyletin, could be constructed (total yield up to 76%) in an aqueous multicomponent reaction in which isoprenyl acetate, propiolic acid, and phloroglucinol were simply mixed and refluxed in water.

An efficient synthesis of bergapten

An efficient synthesis of the linear furanocoumarin, bergapten, is reported. In order to avoid the formation of the angular furanocoumarin, we have adopted iodine as protecting group at the 8 position of the coumarin ring.

Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents

To explore the structural requirements of (+)-cis-khellactone derivatives as novel anti-HIV agents, 24 monosubstituted 3',4'-di-O-(S)- camphanoyl-(+)-cis-khellactone (DCK) derivatives were synthesized asymmetrically. These compounds included 4 isomeric monomethoxy analogues (3- 6), 4 isomeric monomethyl analogues (7-10), 4 4-alkyl/aryl-substituted analogues (11-14), and 12 4-methyl-(+)-cis-khellactone derivatives (15-26) with varying 3',4'-substituents. These (+)-cis-khellactone derivatives were screened against HIV-1 replication in acutely infected H9 lymphocytes. The results demonstrated that the (3'R,4'R)-(+)-cis-khellactone skeleton, two (S)-(-)-camphanoyl groups at the 3'- and 4'-positions, and a methyl group on the coumarin ring, except at the 6-position, were optimal structural moieties for anti-HIV activity. 3-Methyl- (7), 4-methyl- (8), and 5-methyl- (9) 3',4'- di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone showed EC50 and therapeutic index values of -5 μM and >2.15 x 106, respectively, in H9 lymphocytes, which are much better than those of DCK and AZT in the same assay. Furthermore, 8 and 9 also showed potent inhibitory activity against HIV-1 replication in the CEM-SS cell line, and most monosubstituted DCK analogues were less toxic than DCK in both assays.