3067-14-9 Usage
Description
CCRIS 799, also known as Benzo[a]pyrene-3,6-quinone, is a metabolite of Benzopyrene (B205800). It is known for its ability to induce epidermal growth factor receptor (EGFR) cell signaling in human mammary epithelial cells. Additionally, it is recognized for its high mutagenicity and carcinogenicity.
Uses
Used in Research and Development:
CCRIS 799 is used as a research compound for studying the effects of EGFR cell signaling in human mammary epithelial cells. Its mutagenicity and carcinogenicity also make it a valuable tool for understanding the mechanisms behind these processes.
Used in Pharmaceutical Industry:
CCRIS 799 is used as a reference compound in the development of drugs targeting EGFR cell signaling pathways. Its properties can help researchers identify potential therapeutic agents that can modulate these pathways and potentially treat related conditions.
Used in Environmental and Occupational Health:
CCRIS 799 is used as a marker for assessing the presence of environmental pollutants and occupational exposure to carcinogenic substances. Monitoring the levels of this compound can provide insights into the potential health risks associated with exposure to certain pollutants.
Used in Toxicology Studies:
CCRIS 799 is used as a test compound in toxicology studies to evaluate the potential harmful effects of exposure to mutagens and carcinogens. This can help in understanding the mechanisms of toxicity and developing strategies for risk assessment and mitigation.
Check Digit Verification of cas no
The CAS Registry Mumber 3067-14-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,6 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3067-14:
(6*3)+(5*0)+(4*6)+(3*7)+(2*1)+(1*4)=69
69 % 10 = 9
So 3067-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H10O2/c21-17-10-6-11-5-7-13-12-3-1-2-4-14(12)20(22)16-9-8-15(17)18(11)19(13)16/h1-10H
3067-14-9Relevant articles and documents
Photochemical generation of nitric oxide from 6-nitrobenzo[a]pyrene
Fukuhara,Kurihara,Miyata
, p. 8662 - 8666 (2007/10/03)
Photolabile 6-nitrobenzo[a]pyrene (6-nitroBaP) released nitric oxide (NO) under visible-light irradiation. The generation of NO and the concomitant formation of the 6-oxyBaP radical were confirmed by ESR. BaP quinones were also detected as further oxidize
Radical cations of benzo[a]pyrene and 6-substituted derivatives: Reaction with nucleophiles and DNA
Stack,Cremonesi,Hanson,Rogan,Cavalieri
, p. 755 - 760 (2007/10/03)
1. Oxidation of benzo[a]pyrene (BP) by I2 in the presence of AgClO4 in benzene generates the BP.+ ClO4- · AgI complex. This same method was used to produce radical cations from 6-FBP, 6-ClBP, 6-BrBP and 6-CH3BP. 2. Reaction of the BP,6-FBP,6-ClBP and 6-BrBP radical cation perchlorates with H2O produced BP 1,6-, 3,6- and 6,12- dione, whereas 6-CH3BP.+ClO4- · AgI yielded 6-CH2OHBP. 3. When BP.+ClO4- · AgI and 6-FBP.+ClO4- · AgI were reacted with NaOAc in H2O/CH3CN (9:1), 6-OAcBP was formed, in addition to the quinones. In the case of 6-CIBP.+ClO4- · AgI, a small amount of 1-OAc-6-ClBP and 3-OAc-6-ClBP was formed in, addition to the diones, whereas for 6-BrBP and 6-CH3BP the reaction products were BP diones and 6-CH2OHBP respectively. 4. These results confirm the localization of charge in the BP.+ at C-6, followed by C-1 and C-3. 5. The reaction of BP with NOBF4 in CH2Cl2 produced BP.+ BF4-, radical cation free of complexation with inorganic salts. 6. Reaction of BP.+BF4- with DNA produced the depurinating adducts BP-6-C8Gua, BP-6-C8dGua and BP-6-N7Gua.
Photooxygenation of polycyclic aromatic hydrocarbons by pyrimido[5,4-g]pteridine N-oxide
Sako,Ohara,Hirota,Maki
, p. 2676 - 2680 (2007/10/02)
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