306996-53-2

Basic information

• Product Name: 2-[(3-chloropropanoyl)amino]benzamide
• Synonyms: 2-[(3-chloropropanoyl)amino]benzamide;2-[(3-chloro-1-oxopropyl)amino]benzamide
• CAS NO: 306996-53-2
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.65954
• Mol File: 306996-53-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(3-chloropropanoyl)amino]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-chloropropanoyl)amino]benzamide(306996-53-2)
• EPA Substance Registry System: 2-[(3-chloropropanoyl)amino]benzamide(306996-53-2)

Safety Data

• Hazardous Substances Data: 306996-53-2(Hazardous Substances Data)

Usage

Benzamide derivative

It is a derivative of benzamide, which is a basic structure consisting of a benzene ring connected to a carboxamide group (-CONH2).

Chloropropanoyl group

The compound has a chloropropanoyl group (-CH2CH2CH2Cl) attached to the amino group (-NH2) of the benzamide.

Amino group

The presence of an amino group in the structure contributes to its potential pharmacological and therapeutic properties.

Chemical research and pharmaceutical development

2-[(3-chloropropanoyl)amino]benzamide is often used in these fields due to its potential properties and applications.

Synthesis of other organic compounds

The compound may be used as a building block or intermediate in the synthesis of other organic compounds.

Ongoing research and exploration

The precise applications and characteristics of 2-[(3-chloropropanoyl)amino]benzamide in various fields are still being studied and explored.

Upstream product

• 28144-70-9 anthranilic acid amide 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 1414871-33-2 3-benzyl-2-ethenylquinazolin-4(3H)-one 

Relevant articles and documents

New isoxazolidine-conjugates of quinazolinones-synthesis, antiviral and cytostatic activity

A novel series of (3-diethoxyphosphoryl)isoxazolidines substituted at C5 with various quinazolinones have been synthesized by the 1,3-dipolar cycloaddition of N-methyl-C- (diethoxyphosphoryl)nitrone with N3-substitued 2-vinyl-3H-quinazolin-4-ones. All isoxazolidines were assessed for antiviral activity against a broad range of DNA and RNA viruses. Isoxazolidines trans-11f/cis-11f (90:10), trans-11h and trans-11i/cis-11i (97:3) showed weak activity (EC50 = 6.84, 15.29 and 9.44 μM) toward VZV (TK+ strain) which was only one order of magnitude lower than that of acyclovir used as a reference drug. Phosphonates trans-11b/cis-11b (90:10), trans-11c, trans-11e/cis-11e (90:10) and trans-11g appeared slightly active toward cytomegalovirus (EC50 = 27-45 μM). Compounds containing benzyl substituents at N3 in the quinazolinone skeleton exhibited slight antiproliferative activity towards the tested immortalized cells with IC50 in the 21-102 M range.

Synthesis and reactions of some 2-Vinyl-3H-quinazolin-4-ones

A simple, high-yielding synthesis of 2-vinyl-3H-quinazolin-4-one, 2-(1-chlorovinyl)-3H-quinazolin-4-one and 2-(1-bromovinyl)-3H-quinazolin-4-one. The 2-vinylquinazolinones 11a and 14 participate readily in nucleophilic addition reactions. Treatment with both carbon and nitrogen nucleophiles results in a clean conversion into a variety of 2-substituted 3H-quinazolin-4-one derivatives. The 2-(1-halovinyl)-3H-quinazolin-4-ones 11b and 11c reacted with carbon nucleophiles to give several derivatives of 2-substituted 3H-quinazolin-4-one, such as dihydrofurancarboxylic ethyl ester 23. (C) 2000 Elsevier Science Ltd.