30708-54-4

Basic information

• Product Name: 1-azabicyclo[3.2.2]nonan-4-one
• Synonyms: 1-azabicyclo[3.2.2]nonan-4-one
• CAS NO: 30708-54-4
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.19492
• Mol File: 30708-54-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 120-121 °C
• Boiling Point: 233.6±13.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 8.24±0.20(Predicted)
• CAS DataBase Reference: 1-azabicyclo[3.2.2]nonan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-azabicyclo[3.2.2]nonan-4-one(30708-54-4)
• EPA Substance Registry System: 1-azabicyclo[3.2.2]nonan-4-one(30708-54-4)

Safety Data

• Hazardous Substances Data: 30708-54-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 428, 1985 DOI: 10.1021/ja00288a025

Upstream product

• 18107-18-1 diazomethyl-trimethyl-silane 
• 3731-38-2 3-Quinuclidinone 
• 186581-53-3 diazomethane 
• 1193-65-3 3-quinuclidinone hydrochloride 

Downstream Products

• 1580437-71-3 1-azabicyclo[3.2.2]nonan-4-yl 1-(4-(4-fluorophenyl)pyrimidin-2-yl)piperidine-4-carboxylate 
• 1312555-68-2 7-(benzyloxy)-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 
• 1312555-40-0 7-[(E)-2-(4-chlorophenyl)vinyl]-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 
• 1220279-85-5 9-fluoro-6-[3-fluoro-4-(trifluoromethyl)benzyl]-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole trifluoroacetate 
• 1220278-15-8 9-(methylsulfonyl)-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 
• 93756-96-8 C₁₅H₂₁N₃O₂S 

Relevant articles and documents

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

BRIDGEHEAD AMINE RING-FUSED INDOLES AND INDOLINES

The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R2, R3, h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.

Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety

Balanol is a potent protein kinase C (PKC) inhibitor that is structurally composed of a benzophenone diacid, a 4-hydroxybenzamide, and a perhydroazepine ring. A number of balanol analogs in which the perhydroazepine moiety is replaced have been synthesized and their biological activities evaluated against both PKC and cAMP-dependent kinase (PKA). The results suggested that the activity and the isozyme/kinase selectivity of these compounds are largely related to the conformation about this nonaromatic structural element of the molecules.